Microglial Dysregulation in Psychiatric Disease
Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain. More recently, they have been shown to have a number of important roles beyond immune surveillance and response, includin...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/608654 |
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| _version_ | 1832563563783258112 |
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| author | Luciana Romina Frick Kyle Williams Christopher Pittenger |
| author_facet | Luciana Romina Frick Kyle Williams Christopher Pittenger |
| author_sort | Luciana Romina Frick |
| collection | DOAJ |
| description | Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain. More recently, they have been shown to have a number of important roles beyond immune surveillance and response, including synaptic pruning during development and the support of adult neurogenesis. Microglial abnormalities have been found in several neuropsychiatric conditions, though in most cases it remains unclear whether these are causative or are a reaction to some other underlying pathophysiology. Here we summarize postmortem, animal, neuroimaging, and other evidence for microglial pathology in major depression, schizophrenia, autism, obsessive-compulsive disorder, and Tourette syndrome. We identify gaps in the existing literature and important areas for future research. If microglial pathology proves to be an important causative factor in these or other neuropsychiatric diseases, modulators of microglial function may represent a novel therapeutic strategy. |
| format | Article |
| id | doaj-art-6c71db737683447fa6e87f114eeb6418 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-6c71db737683447fa6e87f114eeb64182025-02-03T01:13:12ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/608654608654Microglial Dysregulation in Psychiatric DiseaseLuciana Romina Frick0Kyle Williams1Christopher Pittenger2Department of Psychiatry, Yale University School of Medicine, 34 Park Street, W315, New Haven, CT 06519, USADepartment of Psychiatry, Yale University School of Medicine, 34 Park Street, W315, New Haven, CT 06519, USADepartment of Psychiatry, Yale University School of Medicine, 34 Park Street, W315, New Haven, CT 06519, USAMicroglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain. More recently, they have been shown to have a number of important roles beyond immune surveillance and response, including synaptic pruning during development and the support of adult neurogenesis. Microglial abnormalities have been found in several neuropsychiatric conditions, though in most cases it remains unclear whether these are causative or are a reaction to some other underlying pathophysiology. Here we summarize postmortem, animal, neuroimaging, and other evidence for microglial pathology in major depression, schizophrenia, autism, obsessive-compulsive disorder, and Tourette syndrome. We identify gaps in the existing literature and important areas for future research. If microglial pathology proves to be an important causative factor in these or other neuropsychiatric diseases, modulators of microglial function may represent a novel therapeutic strategy.http://dx.doi.org/10.1155/2013/608654 |
| spellingShingle | Luciana Romina Frick Kyle Williams Christopher Pittenger Microglial Dysregulation in Psychiatric Disease Clinical and Developmental Immunology |
| title | Microglial Dysregulation in Psychiatric Disease |
| title_full | Microglial Dysregulation in Psychiatric Disease |
| title_fullStr | Microglial Dysregulation in Psychiatric Disease |
| title_full_unstemmed | Microglial Dysregulation in Psychiatric Disease |
| title_short | Microglial Dysregulation in Psychiatric Disease |
| title_sort | microglial dysregulation in psychiatric disease |
| url | http://dx.doi.org/10.1155/2013/608654 |
| work_keys_str_mv | AT lucianarominafrick microglialdysregulationinpsychiatricdisease AT kylewilliams microglialdysregulationinpsychiatricdisease AT christopherpittenger microglialdysregulationinpsychiatricdisease |