Recent advances in the biosynthesis and production optimization of gentamicin: A critical review
Gentamicin, an aminoglycoside antibiotic, is generated by a few species within the genus Micromonospora and has garnered significant attention due to its broad-spectrum efficacy in combating numerous infectious diseases. Comprising a complex array of closely related aminoglycoside compounds, the gen...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Synthetic and Systems Biotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405805X24001418 |
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| author | Feng Xu Kaihao Hu Ali Mohsin Jie Wu Lihuan Su Yuan Wang Rong Ben Hao Gao Xiwei Tian Ju Chu |
| author_facet | Feng Xu Kaihao Hu Ali Mohsin Jie Wu Lihuan Su Yuan Wang Rong Ben Hao Gao Xiwei Tian Ju Chu |
| author_sort | Feng Xu |
| collection | DOAJ |
| description | Gentamicin, an aminoglycoside antibiotic, is generated by a few species within the genus Micromonospora and has garnered significant attention due to its broad-spectrum efficacy in combating numerous infectious diseases. Comprising a complex array of closely related aminoglycoside compounds, the gentamicin B and C complexes emerge as particularly pertinent in clinical contexts. This review outlines the latest advancements in the biosynthesis and production of gentamicin, commencing with a comprehensive overview of its biosynthetic pathway. Subsequently, the article encapsulates a spectrum of strategies currently deployed to augment gentamicin yields. These strategies include mutation screening, molecular biological techniques, and optimization of the fermentation process. Moreover, numerous methods have been documented for detecting gentamicin across a range of matrices, underscoring the significance of precise quantitative analysis. Finally, the review furnishes an exhaustive market analysis and future outlook, elucidating prevailing trends and challenges within the gentamicin industry. Overall, this article serves as a pivotal resource for researchers and professionals engaged in gentamicin research, furnishing a meticulous introduction to efficient synthesis technologies and diverse applications, alongside presenting innovative concepts and methodologies aimed at increasing gentamicin production. |
| format | Article |
| id | doaj-art-6c71aaba88514fc8940f2e8e0eb2dbfc |
| institution | OA Journals |
| issn | 2405-805X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Synthetic and Systems Biotechnology |
| spelling | doaj-art-6c71aaba88514fc8940f2e8e0eb2dbfc2025-08-20T02:24:59ZengKeAi Communications Co., Ltd.Synthetic and Systems Biotechnology2405-805X2025-03-0110124726110.1016/j.synbio.2024.11.003Recent advances in the biosynthesis and production optimization of gentamicin: A critical reviewFeng Xu0Kaihao Hu1Ali Mohsin2Jie Wu3Lihuan Su4Yuan Wang5Rong Ben6Hao Gao7Xiwei Tian8Ju Chu9Qingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of ChinaQingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of ChinaQingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of ChinaQingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of ChinaQingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of ChinaQingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of ChinaQingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of ChinaQingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of ChinaCorresponding author.; Qingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of ChinaCorresponding author.; Qingdao Innovation Institute of East China University of Science and Technology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of ChinaGentamicin, an aminoglycoside antibiotic, is generated by a few species within the genus Micromonospora and has garnered significant attention due to its broad-spectrum efficacy in combating numerous infectious diseases. Comprising a complex array of closely related aminoglycoside compounds, the gentamicin B and C complexes emerge as particularly pertinent in clinical contexts. This review outlines the latest advancements in the biosynthesis and production of gentamicin, commencing with a comprehensive overview of its biosynthetic pathway. Subsequently, the article encapsulates a spectrum of strategies currently deployed to augment gentamicin yields. These strategies include mutation screening, molecular biological techniques, and optimization of the fermentation process. Moreover, numerous methods have been documented for detecting gentamicin across a range of matrices, underscoring the significance of precise quantitative analysis. Finally, the review furnishes an exhaustive market analysis and future outlook, elucidating prevailing trends and challenges within the gentamicin industry. Overall, this article serves as a pivotal resource for researchers and professionals engaged in gentamicin research, furnishing a meticulous introduction to efficient synthesis technologies and diverse applications, alongside presenting innovative concepts and methodologies aimed at increasing gentamicin production.http://www.sciencedirect.com/science/article/pii/S2405805X24001418MicromonosporaGentamicin biosynthesisFermentation process optimizationMolecular regulationAminoglycosides |
| spellingShingle | Feng Xu Kaihao Hu Ali Mohsin Jie Wu Lihuan Su Yuan Wang Rong Ben Hao Gao Xiwei Tian Ju Chu Recent advances in the biosynthesis and production optimization of gentamicin: A critical review Synthetic and Systems Biotechnology Micromonospora Gentamicin biosynthesis Fermentation process optimization Molecular regulation Aminoglycosides |
| title | Recent advances in the biosynthesis and production optimization of gentamicin: A critical review |
| title_full | Recent advances in the biosynthesis and production optimization of gentamicin: A critical review |
| title_fullStr | Recent advances in the biosynthesis and production optimization of gentamicin: A critical review |
| title_full_unstemmed | Recent advances in the biosynthesis and production optimization of gentamicin: A critical review |
| title_short | Recent advances in the biosynthesis and production optimization of gentamicin: A critical review |
| title_sort | recent advances in the biosynthesis and production optimization of gentamicin a critical review |
| topic | Micromonospora Gentamicin biosynthesis Fermentation process optimization Molecular regulation Aminoglycosides |
| url | http://www.sciencedirect.com/science/article/pii/S2405805X24001418 |
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