Alternative splicing: A key regulator in T cell response and cancer immunotherapy

Alternative splicing: A key regulator in T cell response and cancer immunotherapy

Alternative splicing (AS), a key post-transcriptional regulatory mechanism, is frequently dysregulated in cancer, driving both tumor progression and immune modulation. Aberrant AS influences antigen presentation, T cell activation, immune checkpoint regulation, and cytokine signaling, contributing t...

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Bibliographic Details
Main Authors: Caiyu Yong, Yexin Liang, Minmin Wang, Weiwei Jin, Xuefei Fan, Zhengwen Wang, Kui Cao, Tong Wu, Qian Li, Cunjie Chang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Pharmacological Research
Subjects:
Alternative splicing
Neoantigen
T-cell response
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825001380
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