Cysteine-10 on 17β-Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals

Cysteine-10 on 17β-Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) catalyzes the conversion of estrone to the potent estrogen estradiol. 17β-HSD1 is highly expressed in breast and ovary tissues and represents a prognostic marker for the tumor progression and survival of patients with breast cancer and other estroge...

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Bibliographic Details
Main Authors:	Lyubomir G. Nashev, Atanas G. Atanasov, Michael E. Baker, Alex Odermatt
Format:	Article
Language:	English
Published:	Wiley 2013-01-01
Series:	International Journal of Cell Biology
Online Access:	http://dx.doi.org/10.1155/2013/769536
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