Unique skin nodules following COVID-19 vaccination: a case report of cutaneous plasmacytosis and review of the literature
Abstract Background Cutaneous plasmacytosis (CP) is a rare disorder that may affect two or more organ systems, such as skin, lymph nodes or lungs. The pathogenesis of CP remains unknown, and in most cases, the condition follows a chronic and benign clinical course without spontaneous remission. Case...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-03-01
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| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-025-02653-6 |
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| Summary: | Abstract Background Cutaneous plasmacytosis (CP) is a rare disorder that may affect two or more organ systems, such as skin, lymph nodes or lungs. The pathogenesis of CP remains unknown, and in most cases, the condition follows a chronic and benign clinical course without spontaneous remission. Case presentation A 50-year-old male who developed necrotizing skin nodules without other systemic abnormalities four days after the first doses of the Coronavirus disease 2019 (COVID-19) vaccination. Oral prednisone improved the lesions by approximately 70%. However, signs of CP recurrence manifested 15 days after the second dose of COVID-19 vaccination. Ultimately, the patient experienced spontaneous remission after contracting SARS-CoV-2 infection. Conclusion This case uniquely associates COVID-19 inactivated vaccine with CP, where the same lesions appeared after two vaccinations and subsequently resolved following SARS-CoV-2 infection. This provides valuable clinical data for future studies on viral infections and cutaneous B-cell immunity. |
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| ISSN: | 1743-422X |