A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets

Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared...

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Main Authors: Refaat Ahmed, Sokar Magda, Ismail Fatma, Boraei Nabila
Format: Article
Language:English
Published: Sciendo 2016-12-01
Series:Acta Pharmaceutica
Subjects:
Online Access:https://doi.org/10.1515/acph-2016-0041
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author Refaat Ahmed
Sokar Magda
Ismail Fatma
Boraei Nabila
author_facet Refaat Ahmed
Sokar Magda
Ismail Fatma
Boraei Nabila
author_sort Refaat Ahmed
collection DOAJ
description Quetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol and white beeswax either alone or in mixtures. They showed sustained QT release and a taste masking effect. The selected QT SLMP was further blended with an aqueous solution containing polyvinylpyrollidone (2.5 %), croscarmellose sodium (2 %) and mannitol (50 %); it was then lyophilized into ODT in a mass ratio of 1:2, respectively. ODTs containing QT SLMPs showed: average wetting time (40.92 s), average oral disintegration time (21.49 s), average hardness (16.85 N) and also imparted suitable viscosity to suspend pellets during the lyophilization process. In conclusion, lyophilization is a promising technique for the formulation of multiparticulate systems into ODTs.
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institution Kabale University
issn 1846-9558
language English
publishDate 2016-12-01
publisher Sciendo
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series Acta Pharmaceutica
spelling doaj-art-6c5807b6eb444991ab6182de00f3b7d42025-02-02T10:06:42ZengSciendoActa Pharmaceutica1846-95582016-12-0166451553210.1515/acph-2016-0041acph-2016-0041A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tabletsRefaat Ahmed0Sokar Magda1Ismail Fatma2Boraei Nabila3Pharmaceutics Department, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptPharmaceutics Department, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptPharmaceutics Department, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptPharmaceutics Department, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptQuetiapine (QT) is a short acting atypical antipsychotic drug effective in schizophrenia and bipolar disorder. This study aims at designing a novel dosage form of sustained release taste-masked QT orally disintegrating tablets (ODTs) based on solid lipid micro-pellets (SLMPs). QT SLMPs were prepared using the hot melt extrusion technique and utilizing three lipid carriers: Compritol, Precirol and white beeswax either alone or in mixtures. They showed sustained QT release and a taste masking effect. The selected QT SLMP was further blended with an aqueous solution containing polyvinylpyrollidone (2.5 %), croscarmellose sodium (2 %) and mannitol (50 %); it was then lyophilized into ODT in a mass ratio of 1:2, respectively. ODTs containing QT SLMPs showed: average wetting time (40.92 s), average oral disintegration time (21.49 s), average hardness (16.85 N) and also imparted suitable viscosity to suspend pellets during the lyophilization process. In conclusion, lyophilization is a promising technique for the formulation of multiparticulate systems into ODTs.https://doi.org/10.1515/acph-2016-0041solid lipid micro pelletsmultiparticulatequetiapineorally disintegrating tablets
spellingShingle Refaat Ahmed
Sokar Magda
Ismail Fatma
Boraei Nabila
A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets
Acta Pharmaceutica
solid lipid micro pellets
multiparticulate
quetiapine
orally disintegrating tablets
title A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets
title_full A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets
title_fullStr A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets
title_full_unstemmed A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets
title_short A dual strategy to improve psychotic patients’ compliance using sustained release quetiapine oral disintegrating tablets
title_sort dual strategy to improve psychotic patients compliance using sustained release quetiapine oral disintegrating tablets
topic solid lipid micro pellets
multiparticulate
quetiapine
orally disintegrating tablets
url https://doi.org/10.1515/acph-2016-0041
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