LONG-TERM EFFECTS OF OLMESARTAN, AN ANG II RECEPTOR ANTAGONIST, ON BLOOD PRESSURE AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS
The object of this study is to evaluate the long-term effects of olmesartan on hypertension and the renin-angiotensinaldosterone system in hypertensive patients. This study evaluated 26 hypertensive male and female outpatients, 38-69 years of age, with a systolic blood pressure ≥160 mm Hg and/or a d...
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«FIRMA «SILICEA» LLC
2011-06-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1105 |
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| author | Shuichi Ichikawa Yoshiaki Takayama |
| author_facet | Shuichi Ichikawa Yoshiaki Takayama |
| author_sort | Shuichi Ichikawa |
| collection | DOAJ |
| description | The object of this study is to evaluate the long-term effects of olmesartan on hypertension and the renin-angiotensinaldosterone system in hypertensive patients. This study evaluated 26 hypertensive male and female outpatients, 38-69 years of age, with a systolic blood pressure ≥160 mm Hg and/or a diastolic blood pressure ≥95 mm Hg. Oral doses of 5 to 40 mg olmesartan were administered once daily. Blood pressure and renin-angiotensin-aldosterone parameters (plasma renin activity and plasma angiotensin I, II, and aldosterone concentrations) were evaluated at 12-16 weeks, 6 months, and 1 year after the start of olmesartan administration. Systolic and diastolic blood pressures were significantly decreased following the administration of olmesartan. The observed decreases in systolic and diastolic blood pressures after 1 year of treatment were 28,8±2,1 mm Hg and 15,8±1,3 mm Hg, respectively. No change was observed in the pulse rate. The plasma renin activity increased significantly from a baseline premedication mean of 1,26±0,31 ng/ml/h to a mean of 2,58±0,74 ng/ml/h and 2,87±0,72 ng/ml/h after 6 months and 1 year of treatment, respectively. Angiotensin II levels decreased significantly from a baseline of 20,4±3,2 pg/ml to a mean of 8,6±2,1 pg/ml and 6,8±1,8 pg/ml after 6 months and 1 year of treatment, respectively. The plasma aldosterone level also decreased significantly after 6 months of treatment. In hypertensive patients, the long-term administration of olmesartan, a novel AT, receptor antagonist, decreased both blood pressure and plasma angiotensin II levels. |
| format | Article |
| id | doaj-art-6c3c8dae345f40d0aa4cdf22e6e4ef44 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2011-06-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj-art-6c3c8dae345f40d0aa4cdf22e6e4ef442025-08-20T03:00:21Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202011-06-01033339911LONG-TERM EFFECTS OF OLMESARTAN, AN ANG II RECEPTOR ANTAGONIST, ON BLOOD PRESSURE AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTSShuichi Ichikawa0Yoshiaki Takayama1Отдел медицины внутренних органовОтдел медицины внутренних органовThe object of this study is to evaluate the long-term effects of olmesartan on hypertension and the renin-angiotensinaldosterone system in hypertensive patients. This study evaluated 26 hypertensive male and female outpatients, 38-69 years of age, with a systolic blood pressure ≥160 mm Hg and/or a diastolic blood pressure ≥95 mm Hg. Oral doses of 5 to 40 mg olmesartan were administered once daily. Blood pressure and renin-angiotensin-aldosterone parameters (plasma renin activity and plasma angiotensin I, II, and aldosterone concentrations) were evaluated at 12-16 weeks, 6 months, and 1 year after the start of olmesartan administration. Systolic and diastolic blood pressures were significantly decreased following the administration of olmesartan. The observed decreases in systolic and diastolic blood pressures after 1 year of treatment were 28,8±2,1 mm Hg and 15,8±1,3 mm Hg, respectively. No change was observed in the pulse rate. The plasma renin activity increased significantly from a baseline premedication mean of 1,26±0,31 ng/ml/h to a mean of 2,58±0,74 ng/ml/h and 2,87±0,72 ng/ml/h after 6 months and 1 year of treatment, respectively. Angiotensin II levels decreased significantly from a baseline of 20,4±3,2 pg/ml to a mean of 8,6±2,1 pg/ml and 6,8±1,8 pg/ml after 6 months and 1 year of treatment, respectively. The plasma aldosterone level also decreased significantly after 6 months of treatment. In hypertensive patients, the long-term administration of olmesartan, a novel AT, receptor antagonist, decreased both blood pressure and plasma angiotensin II levels.https://russjcardiol.elpub.ru/jour/article/view/1105angiotensin ii receptor antagonistsolmesartanrenin-angiotensin-aldosterone system |
| spellingShingle | Shuichi Ichikawa Yoshiaki Takayama LONG-TERM EFFECTS OF OLMESARTAN, AN ANG II RECEPTOR ANTAGONIST, ON BLOOD PRESSURE AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS Российский кардиологический журнал angiotensin ii receptor antagonists olmesartan renin-angiotensin-aldosterone system |
| title | LONG-TERM EFFECTS OF OLMESARTAN, AN ANG II RECEPTOR ANTAGONIST, ON BLOOD PRESSURE AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS |
| title_full | LONG-TERM EFFECTS OF OLMESARTAN, AN ANG II RECEPTOR ANTAGONIST, ON BLOOD PRESSURE AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS |
| title_fullStr | LONG-TERM EFFECTS OF OLMESARTAN, AN ANG II RECEPTOR ANTAGONIST, ON BLOOD PRESSURE AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS |
| title_full_unstemmed | LONG-TERM EFFECTS OF OLMESARTAN, AN ANG II RECEPTOR ANTAGONIST, ON BLOOD PRESSURE AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS |
| title_short | LONG-TERM EFFECTS OF OLMESARTAN, AN ANG II RECEPTOR ANTAGONIST, ON BLOOD PRESSURE AND THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS |
| title_sort | long term effects of olmesartan an ang ii receptor antagonist on blood pressure and the renin angiotensin aldosterone system in hypertensive patients |
| topic | angiotensin ii receptor antagonists olmesartan renin-angiotensin-aldosterone system |
| url | https://russjcardiol.elpub.ru/jour/article/view/1105 |
| work_keys_str_mv | AT shuichiichikawa longtermeffectsofolmesartananangiireceptorantagonistonbloodpressureandthereninangiotensinaldosteronesysteminhypertensivepatients AT yoshiakitakayama longtermeffectsofolmesartananangiireceptorantagonistonbloodpressureandthereninangiotensinaldosteronesysteminhypertensivepatients |