MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids
MicroRNAs (miRNAs) are pivotal post-transcriptional regulators that orchestrate gene expression programs governing cancer initiation, progression, metastasis, and therapeutic resistance. Among their many targets, the WNT signaling pathway, a key driver of malignancy, is tightly controlled by miRNAs,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1616221/full |
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| author | Akanksha Gupta Arpit Mehrotra Abhilasha Sood Bunty Sharma Vikas Yadav Ginpreet Kaur Katrin Sak Shakti Ranjan Satapathy Hardeep Singh Tuli |
| author_facet | Akanksha Gupta Arpit Mehrotra Abhilasha Sood Bunty Sharma Vikas Yadav Ginpreet Kaur Katrin Sak Shakti Ranjan Satapathy Hardeep Singh Tuli |
| author_sort | Akanksha Gupta |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are pivotal post-transcriptional regulators that orchestrate gene expression programs governing cancer initiation, progression, metastasis, and therapeutic resistance. Among their many targets, the WNT signaling pathway, a key driver of malignancy, is tightly controlled by miRNAs, forming intricate feedback loops that shape tumor behavior. Concurrently, flavonoids, naturally occurring plant-derived polyphenols, are emerging as promising anticancer agents that can modulate both WNT signaling and miRNA expression. This review highlights miRNAs as the central regulators of oncogenic signaling, focusing on their dualistic role in cancer biology and their modulation by flavonoids. We explore the mechanistic frameworks underpinning miRNA-WNT interactions and the therapeutic potential of flavonoid-mediated miRNA reprogramming for precision miRNA targeting. Unraveling this regulatory axis offers a promising avenue for developing multi-targeted therapies and personalized cancer treatment strategies. |
| format | Article |
| id | doaj-art-6c3b45dbfafd4d6ca835306d4a940b80 |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-6c3b45dbfafd4d6ca835306d4a940b802025-08-20T03:41:54ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-08-011210.3389/fmolb.2025.16162211616221MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoidsAkanksha Gupta0Arpit Mehrotra1Abhilasha Sood2Bunty Sharma3Vikas Yadav4Ginpreet Kaur5Katrin Sak6Shakti Ranjan Satapathy7Hardeep Singh Tuli8Department of Pharmacology, Shobha Ben Pratap Bhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS, Mumbai, IndiaDepartment of Allied Health Sciences, Chitkara School of Health Sciences, Chitkara University, Rajpura, Punjab, IndiaDepartment of Allied Health Sciences, Chitkara School of Health Sciences, Chitkara University, Rajpura, Punjab, IndiaDepartment of Biotechnology, Graphic Era (Deemed to be University), Dehradun, Uttarakhand, IndiaCell and Experimental Pathology, Department of Translational Medicine, Skåne University Hospital, Lund University, Malmö, SwedenDepartment of Pharmacology, Shobha Ben Pratap Bhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS, Mumbai, IndiaNGO Praeventio, Tartu, EstoniaCell and Experimental Pathology, Department of Translational Medicine, Skåne University Hospital, Lund University, Malmö, SwedenCentre of Excellence in Computational Research and Drug Discovery, Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana, IndiaMicroRNAs (miRNAs) are pivotal post-transcriptional regulators that orchestrate gene expression programs governing cancer initiation, progression, metastasis, and therapeutic resistance. Among their many targets, the WNT signaling pathway, a key driver of malignancy, is tightly controlled by miRNAs, forming intricate feedback loops that shape tumor behavior. Concurrently, flavonoids, naturally occurring plant-derived polyphenols, are emerging as promising anticancer agents that can modulate both WNT signaling and miRNA expression. This review highlights miRNAs as the central regulators of oncogenic signaling, focusing on their dualistic role in cancer biology and their modulation by flavonoids. We explore the mechanistic frameworks underpinning miRNA-WNT interactions and the therapeutic potential of flavonoid-mediated miRNA reprogramming for precision miRNA targeting. Unraveling this regulatory axis offers a promising avenue for developing multi-targeted therapies and personalized cancer treatment strategies.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1616221/fullwnt signalingmicroRNAcancerflavonoidsapoptosismetastasis |
| spellingShingle | Akanksha Gupta Arpit Mehrotra Abhilasha Sood Bunty Sharma Vikas Yadav Ginpreet Kaur Katrin Sak Shakti Ranjan Satapathy Hardeep Singh Tuli MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids Frontiers in Molecular Biosciences wnt signaling microRNA cancer flavonoids apoptosis metastasis |
| title | MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids |
| title_full | MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids |
| title_fullStr | MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids |
| title_full_unstemmed | MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids |
| title_short | MicroRNAs at the crossroad of cancer therapeutics: insights from WNT signaling & flavonoids |
| title_sort | micrornas at the crossroad of cancer therapeutics insights from wnt signaling flavonoids |
| topic | wnt signaling microRNA cancer flavonoids apoptosis metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1616221/full |
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