MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia

The spiral arteries undergo physiologic changes during pregnancy, and the failure of this process may lead to a spectrum of pregnancy disorders, including pre-eclampsia. Our recent data indicate that decidual endothelial cells (DECs), covering the inner side of the spiral arteries, acquire the abili...

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Main Authors: Chiara Agostinis, Fleur Bossi, Elisa Masat, Oriano Radillo, Maddalena Tonon, Francesco De Seta, Francesco Tedesco, Roberta Bulla
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2012/484321
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author Chiara Agostinis
Fleur Bossi
Elisa Masat
Oriano Radillo
Maddalena Tonon
Francesco De Seta
Francesco Tedesco
Roberta Bulla
author_facet Chiara Agostinis
Fleur Bossi
Elisa Masat
Oriano Radillo
Maddalena Tonon
Francesco De Seta
Francesco Tedesco
Roberta Bulla
author_sort Chiara Agostinis
collection DOAJ
description The spiral arteries undergo physiologic changes during pregnancy, and the failure of this process may lead to a spectrum of pregnancy disorders, including pre-eclampsia. Our recent data indicate that decidual endothelial cells (DECs), covering the inner side of the spiral arteries, acquire the ability to synthesize C1q, which acts as a link between endovascular trophoblast and DECs favouring the process of vascular remodelling. In this study, we have shown that sera obtained from pre-eclamptic patients strongly inhibit the interaction between extravillous trophoblast (EVT) and DECs, preventing endovascular invasion of trophoblast cells. We further demonstrated that mannose-binding lectin (MBL), one of the factor increased in pre-eclamptic patient sera, strongly inhibits the interaction of EVT with C1q interfering with the process of EVT adhesion to and migration through DECs. These data suggest that the increased level of MBL in pre-eclampsia may contribute to the failure of the endovascular invasion of trophoblast cells.
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institution Kabale University
issn 1740-2522
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publishDate 2012-01-01
publisher Wiley
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series Clinical and Developmental Immunology
spelling doaj-art-6c369f7124fc4979a32da067629664972025-02-03T05:53:20ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/484321484321MBL Interferes with Endovascular Trophoblast Invasion in Pre-EclampsiaChiara Agostinis0Fleur Bossi1Elisa Masat2Oriano Radillo3Maddalena Tonon4Francesco De Seta5Francesco Tedesco6Roberta Bulla7Institute for Maternal and Child Health, IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyDepartment of Life Sciences, University of Trieste, Via Valerio 28, 34127 Trieste, ItalyDepartment of Life Sciences, University of Trieste, Via Valerio 28, 34127 Trieste, ItalyInstitute for Maternal and Child Health, IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyInstitute for Maternal and Child Health, IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyInstitute for Maternal and Child Health, IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyDepartment of Life Sciences, University of Trieste, Via Valerio 28, 34127 Trieste, ItalyDepartment of Life Sciences, University of Trieste, Via Valerio 28, 34127 Trieste, ItalyThe spiral arteries undergo physiologic changes during pregnancy, and the failure of this process may lead to a spectrum of pregnancy disorders, including pre-eclampsia. Our recent data indicate that decidual endothelial cells (DECs), covering the inner side of the spiral arteries, acquire the ability to synthesize C1q, which acts as a link between endovascular trophoblast and DECs favouring the process of vascular remodelling. In this study, we have shown that sera obtained from pre-eclamptic patients strongly inhibit the interaction between extravillous trophoblast (EVT) and DECs, preventing endovascular invasion of trophoblast cells. We further demonstrated that mannose-binding lectin (MBL), one of the factor increased in pre-eclamptic patient sera, strongly inhibits the interaction of EVT with C1q interfering with the process of EVT adhesion to and migration through DECs. These data suggest that the increased level of MBL in pre-eclampsia may contribute to the failure of the endovascular invasion of trophoblast cells.http://dx.doi.org/10.1155/2012/484321
spellingShingle Chiara Agostinis
Fleur Bossi
Elisa Masat
Oriano Radillo
Maddalena Tonon
Francesco De Seta
Francesco Tedesco
Roberta Bulla
MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
Clinical and Developmental Immunology
title MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
title_full MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
title_fullStr MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
title_full_unstemmed MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
title_short MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
title_sort mbl interferes with endovascular trophoblast invasion in pre eclampsia
url http://dx.doi.org/10.1155/2012/484321
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