The Biological Therapy of Cancer
The current status of biological approaches to the therapy of malignancy is reviewed. Biological response modifiers have been used in immunobiological therapeutic strategies, as myelorestorative agents during chemotherapy, as modulators of cytotoxic chemotherapeutic actions, and as adjuncts to the d...
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| Format: | Article |
| Language: | English |
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Wiley
1992-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1992/420495 |
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| _version_ | 1850222943800393728 |
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| author | David R Parkinson |
| author_facet | David R Parkinson |
| author_sort | David R Parkinson |
| collection | DOAJ |
| description | The current
status of biological approaches to the therapy of malignancy is reviewed. Biological response modifiers have
been used in immunobiological therapeutic strategies, as myelorestorative agents during chemotherapy,
as modulators of cytotoxic chemotherapeutic actions, and as adjuncts to the differentiation therapy of
cancer. Immunobiologically active agents currently under study include recombinant cytokines such as
interferons-alpha and -gamma. interleukin (IL)-1 and IL-2. and tumuor necrosis factor. A range of
hematopoietic growth factors are being studied alone or in combination; these include granulocyte-.
granulocyte-macrophage- and macrophage-colony stimulating factors, IL-3 and IL-6. and the recombinant
growth factor PIXY-321. Targetting strategies to cytotoxic cancer therapy including immunoloxin and
radioimmunoconjugate therapy have used monocolonal antibodies and derivative bio-engineered molecules
as targetting modalities. Finally. the recent descriptions of therapeutic successes with retinoid-based
differentiation strategies opens new possibilities for biologically-based treatment of malignancy. |
| format | Article |
| id | doaj-art-6c3140a62bab46bca868703d96dc6c7d |
| institution | OA Journals |
| issn | 1180-2332 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-6c3140a62bab46bca868703d96dc6c7d2025-08-20T02:06:07ZengWileyCanadian Journal of Infectious Diseases1180-23321992-01-013Suppl B263310.1155/1992/420495The Biological Therapy of CancerDavid R ParkinsonThe current status of biological approaches to the therapy of malignancy is reviewed. Biological response modifiers have been used in immunobiological therapeutic strategies, as myelorestorative agents during chemotherapy, as modulators of cytotoxic chemotherapeutic actions, and as adjuncts to the differentiation therapy of cancer. Immunobiologically active agents currently under study include recombinant cytokines such as interferons-alpha and -gamma. interleukin (IL)-1 and IL-2. and tumuor necrosis factor. A range of hematopoietic growth factors are being studied alone or in combination; these include granulocyte-. granulocyte-macrophage- and macrophage-colony stimulating factors, IL-3 and IL-6. and the recombinant growth factor PIXY-321. Targetting strategies to cytotoxic cancer therapy including immunoloxin and radioimmunoconjugate therapy have used monocolonal antibodies and derivative bio-engineered molecules as targetting modalities. Finally. the recent descriptions of therapeutic successes with retinoid-based differentiation strategies opens new possibilities for biologically-based treatment of malignancy.http://dx.doi.org/10.1155/1992/420495 |
| spellingShingle | David R Parkinson The Biological Therapy of Cancer Canadian Journal of Infectious Diseases |
| title | The Biological Therapy of Cancer |
| title_full | The Biological Therapy of Cancer |
| title_fullStr | The Biological Therapy of Cancer |
| title_full_unstemmed | The Biological Therapy of Cancer |
| title_short | The Biological Therapy of Cancer |
| title_sort | biological therapy of cancer |
| url | http://dx.doi.org/10.1155/1992/420495 |
| work_keys_str_mv | AT davidrparkinson thebiologicaltherapyofcancer AT davidrparkinson biologicaltherapyofcancer |