Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models

Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models

Zika virus (ZIKV) remained poorly studied until an outbreak in 2015 linked the virus to severe neurological disorders and congenital malformations. Currently, there are no antiviral drugs or vaccines available. We have previously demonstrated that a simian adenovirus vector vaccine (ChAdOx1 prMEΔTM)...

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Bibliographic Details
Main Authors: Giuditta De Lorenzo, Rapeepat Tandavanitj, Lorena Preciado-Llanes, Ricardo Sanchez-Velazquez, Raissa Prado Rocha, Young Chan Kim, Arturo Reyes-Sandoval, Arvind H. Patel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
ZIKV
vaccine
ChAdOx1
flavivirus
heterologous immunization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578427/full
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