Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models
Zika virus (ZIKV) remained poorly studied until an outbreak in 2015 linked the virus to severe neurological disorders and congenital malformations. Currently, there are no antiviral drugs or vaccines available. We have previously demonstrated that a simian adenovirus vector vaccine (ChAdOx1 prMEΔTM)...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578427/full |
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| author | Giuditta De Lorenzo Giuditta De Lorenzo Rapeepat Tandavanitj Rapeepat Tandavanitj Lorena Preciado-Llanes Ricardo Sanchez-Velazquez Raissa Prado Rocha Young Chan Kim Young Chan Kim Arturo Reyes-Sandoval Arturo Reyes-Sandoval Arvind H. Patel Arvind H. Patel |
| author_facet | Giuditta De Lorenzo Giuditta De Lorenzo Rapeepat Tandavanitj Rapeepat Tandavanitj Lorena Preciado-Llanes Ricardo Sanchez-Velazquez Raissa Prado Rocha Young Chan Kim Young Chan Kim Arturo Reyes-Sandoval Arturo Reyes-Sandoval Arvind H. Patel Arvind H. Patel |
| author_sort | Giuditta De Lorenzo |
| collection | DOAJ |
| description | Zika virus (ZIKV) remained poorly studied until an outbreak in 2015 linked the virus to severe neurological disorders and congenital malformations. Currently, there are no antiviral drugs or vaccines available. We have previously demonstrated that a simian adenovirus vector vaccine (ChAdOx1 prMEΔTM) and a virus-like particle-based vaccine bearing E proteins locked in covalent dimers (VLP-cvD) are effective against ZIKV infection in animal challenge models. In this study, we further explored the efficacy of these vaccines, either individually or in combination, using a heterologous prime and boost vaccination strategy in mouse challenge models. Although the individual vaccines provided good protection levels, the heterologous prime–boost vaccination regimen (ChAdOx1 prMEΔTM followed by VLP-cvD) offered the most effective protection. This regimen elicited a strong cellular response and high levels of neutralising antibodies, which were attributed to ChAdOx1 prMEΔTM and VLP-cvD, respectively. Our findings support the use of combined vaccine technologies and offer valuable insights into the multifactorial protection achievable through heterologous vaccination. These results have important implications for the development of effective vaccination strategies against ZIKV and other emerging viruses. |
| format | Article |
| id | doaj-art-6c2f4dc9069148f88e18a1bf1173e1dd |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-6c2f4dc9069148f88e18a1bf1173e1dd2025-08-20T03:14:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15784271578427Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse modelsGiuditta De Lorenzo0Giuditta De Lorenzo1Rapeepat Tandavanitj2Rapeepat Tandavanitj3Lorena Preciado-Llanes4Ricardo Sanchez-Velazquez5Raissa Prado Rocha6Young Chan Kim7Young Chan Kim8Arturo Reyes-Sandoval9Arturo Reyes-Sandoval10Arvind H. Patel11Arvind H. Patel12MRC-University of Glasgow Centre for Virus Research, Glasgow, United KingdomResearch and Technology Institute, Area Science Park, Trieste, ItalyMRC-University of Glasgow Centre for Virus Research, Glasgow, United KingdomBiologicals Research Group, Research and Development Institute, Government Pharmaceutical Organization, Bangkok, ThailandThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United KingdomMRC-University of Glasgow Centre for Virus Research, Glasgow, United KingdomThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United KingdomDivision of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United KingdomOxford Vaccine Group, Department of Paediatrics, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United KingdomThe Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United KingdomUnidad Adolfo López Mateos, Instituto Politécnico Nacional (IPN), Mexico City, MexicoMRC-University of Glasgow Centre for Virus Research, Glasgow, United KingdomCVR-CRUSH, MRC-University of Glasgow Centre for Virus Research, Glasgow, United KingdomZika virus (ZIKV) remained poorly studied until an outbreak in 2015 linked the virus to severe neurological disorders and congenital malformations. Currently, there are no antiviral drugs or vaccines available. We have previously demonstrated that a simian adenovirus vector vaccine (ChAdOx1 prMEΔTM) and a virus-like particle-based vaccine bearing E proteins locked in covalent dimers (VLP-cvD) are effective against ZIKV infection in animal challenge models. In this study, we further explored the efficacy of these vaccines, either individually or in combination, using a heterologous prime and boost vaccination strategy in mouse challenge models. Although the individual vaccines provided good protection levels, the heterologous prime–boost vaccination regimen (ChAdOx1 prMEΔTM followed by VLP-cvD) offered the most effective protection. This regimen elicited a strong cellular response and high levels of neutralising antibodies, which were attributed to ChAdOx1 prMEΔTM and VLP-cvD, respectively. Our findings support the use of combined vaccine technologies and offer valuable insights into the multifactorial protection achievable through heterologous vaccination. These results have important implications for the development of effective vaccination strategies against ZIKV and other emerging viruses.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578427/fullZIKVvaccineChAdOx1flavivirusheterologous immunization |
| spellingShingle | Giuditta De Lorenzo Giuditta De Lorenzo Rapeepat Tandavanitj Rapeepat Tandavanitj Lorena Preciado-Llanes Ricardo Sanchez-Velazquez Raissa Prado Rocha Young Chan Kim Young Chan Kim Arturo Reyes-Sandoval Arturo Reyes-Sandoval Arvind H. Patel Arvind H. Patel Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models Frontiers in Immunology ZIKV vaccine ChAdOx1 flavivirus heterologous immunization |
| title | Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models |
| title_full | Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models |
| title_fullStr | Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models |
| title_full_unstemmed | Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models |
| title_short | Heterologous prime–boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models |
| title_sort | heterologous prime boost zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models |
| topic | ZIKV vaccine ChAdOx1 flavivirus heterologous immunization |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578427/full |
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