Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compounds
Abstract. Lung cancer is one of the most lethal tumors in the world with a 5-year overall survival rate of less than 20%, mainly including lung adenocarcinoma (LUAD). Tumor microenvironment (TME) has become a new research focus in the treatment of lung cancer. The TME is heterogeneous in composition...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2025-04-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003341 |
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| _version_ | 1850139767775166464 |
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| author | Mingyu Han Feng Wan Bin Xiao Junrong Du Cheng Peng Fu Peng Xiangxiang Pan |
| author_facet | Mingyu Han Feng Wan Bin Xiao Junrong Du Cheng Peng Fu Peng Xiangxiang Pan |
| author_sort | Mingyu Han |
| collection | DOAJ |
| description | Abstract. Lung cancer is one of the most lethal tumors in the world with a 5-year overall survival rate of less than 20%, mainly including lung adenocarcinoma (LUAD). Tumor microenvironment (TME) has become a new research focus in the treatment of lung cancer. The TME is heterogeneous in composition and consists of cellular components, growth factors, proteases, and extracellular matrix. The various cellular components exert a different role in apoptosis, metastasis, or proliferation of lung cancer cells through different pathways, thus contributing to the treatment of adenocarcinoma and potentially facilitating novel therapeutic methods. This review summarizes the research progress on different cellular components with cell–cell interactions in the TME of LUAD, along with their corresponding drug candidates, suggesting that targeting cellular components in the TME of LUAD holds great promise for future theraputic development. |
| format | Article |
| id | doaj-art-6c2a27fe73634700a2d9264caa5a798d |
| institution | OA Journals |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-6c2a27fe73634700a2d9264caa5a798d2025-08-20T02:30:08ZengWolters KluwerChinese Medical Journal0366-69992542-56412025-04-01138890591510.1097/CM9.0000000000003341202504200-00003Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compoundsMingyu Han0Feng Wan1Bin Xiao2Junrong Du3Cheng Peng4Fu Peng5Xiangxiang Pan1 Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China2 State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China4 Chengdu Push Bio-Technology Co., Ltd., Chengdu, Sichuan 610045, China1 Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China2 State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China1 Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, ChinaAbstract. Lung cancer is one of the most lethal tumors in the world with a 5-year overall survival rate of less than 20%, mainly including lung adenocarcinoma (LUAD). Tumor microenvironment (TME) has become a new research focus in the treatment of lung cancer. The TME is heterogeneous in composition and consists of cellular components, growth factors, proteases, and extracellular matrix. The various cellular components exert a different role in apoptosis, metastasis, or proliferation of lung cancer cells through different pathways, thus contributing to the treatment of adenocarcinoma and potentially facilitating novel therapeutic methods. This review summarizes the research progress on different cellular components with cell–cell interactions in the TME of LUAD, along with their corresponding drug candidates, suggesting that targeting cellular components in the TME of LUAD holds great promise for future theraputic development.http://journals.lww.com/10.1097/CM9.0000000000003341 |
| spellingShingle | Mingyu Han Feng Wan Bin Xiao Junrong Du Cheng Peng Fu Peng Xiangxiang Pan Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compounds Chinese Medical Journal |
| title | Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compounds |
| title_full | Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compounds |
| title_fullStr | Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compounds |
| title_full_unstemmed | Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compounds |
| title_short | Cell components of tumor microenvironment in lung adenocarcinoma: Promising targets for small-molecule compounds |
| title_sort | cell components of tumor microenvironment in lung adenocarcinoma promising targets for small molecule compounds |
| url | http://journals.lww.com/10.1097/CM9.0000000000003341 |
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