Analysis of Implant Osseointegration, Bone Repair, and Sinus Mucosa Integrity Using Bio-Oss<sup>®</sup> and Hyaluronic Acid-Polynucleotide Gel (Regenfast<sup>®</sup>) in Maxillary Sinus Augmentation in Rabbits
<b>Background:</b> The combination of polynucleotides and hyaluronic acid with bovine bone grafts in maxillary sinus lift procedures appears to be a promising strategy to enhance bone regeneration. This study aimed to analyze implant osseointegration, bone repair and sinus mucosa integri...
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2025-06-01
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| author | Hiroyuki Omori Daniele Botticelli Erick Ricardo Silva Samuel Porfirio Xavier Sérgio Luis Scombatti de Souza Kaoru Kusano Shunsuke Baba |
| author_facet | Hiroyuki Omori Daniele Botticelli Erick Ricardo Silva Samuel Porfirio Xavier Sérgio Luis Scombatti de Souza Kaoru Kusano Shunsuke Baba |
| author_sort | Hiroyuki Omori |
| collection | DOAJ |
| description | <b>Background:</b> The combination of polynucleotides and hyaluronic acid with bovine bone grafts in maxillary sinus lift procedures appears to be a promising strategy to enhance bone regeneration. This study aimed to analyze implant osseointegration, bone repair and sinus mucosa integrity using Bio-Oss<sup>®</sup> and Hyaluronic Acid-Polynucleotide Gel (Regenfast<sup>®</sup>) in maxillary sinus augmentation in rabbits. <b>Methods:</b> Sinus floor elevation was performed in 12 rabbits, with one implant placed per sinus simultaneously. In the control group, sinuses were grafted with deproteinized bovine bone mineral (Bio-Oss<sup>®</sup>) alone; in the test group, Bio-Oss<sup>®</sup> was combined with Regenfast<sup>®</sup>. Two histological slides were obtained per sinus after 2 weeks (six animals) and 10 weeks (six animals): one from the grafted area alone (non-implant sites), and one from the implant site. Primary outcome variables included the percentage of newly formed bone, the extent of implant osseointegration, and the number of sinus mucosa perforations caused by contact with graft granules. <b>Results:</b> After 10 weeks of healing, the test group showed a significantly higher percentage of new bone formation (37.2 ± 6.7%) compared to the control group (26.8 ± 10.0%; <i>p</i> = 0.031); osseointegration extended to the implant apex in both groups; fewer sinus mucosa perforations were observed in the test group (<i>n</i> = 5) than in the control group (<i>n</i> = 14). <b>Conclusions:</b> The addition of Regenfast<sup>®</sup> to Bio-Oss<sup>®</sup> granules promoted enhanced bone regeneration within the elevated sinus area and was associated with a lower incidence of sinus membrane perforations compared to the use of Bio-Oss<sup>®</sup> alone. |
| format | Article |
| id | doaj-art-6c273bdb12a24aada64f149a2a78e136 |
| institution | DOAJ |
| issn | 2304-6767 |
| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-6c273bdb12a24aada64f149a2a78e1362025-08-20T03:08:05ZengMDPI AGDentistry Journal2304-67672025-06-0113729310.3390/dj13070293Analysis of Implant Osseointegration, Bone Repair, and Sinus Mucosa Integrity Using Bio-Oss<sup>®</sup> and Hyaluronic Acid-Polynucleotide Gel (Regenfast<sup>®</sup>) in Maxillary Sinus Augmentation in RabbitsHiroyuki Omori0Daniele Botticelli1Erick Ricardo Silva2Samuel Porfirio Xavier3Sérgio Luis Scombatti de Souza4Kaoru Kusano5Shunsuke Baba6Department of Oral Implantology, School of Dentistry, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata 573-1121, JapanArdec Academy, 47923 Rimini, ItalyDepartment of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café-Subsetor Oeste 11 (N-11), Ribeirão Preto 14040-904, BrazilDepartment of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café-Subsetor Oeste 11 (N-11), Ribeirão Preto 14040-904, BrazilDepartment of Oral and Maxillofacial Surgery and Periodontics, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Av. do Café-Subsetor Oeste 11 (N-11), Ribeirão Preto 14040-904, BrazilDepartment of Oral Implantology, School of Dentistry, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata 573-1121, JapanDepartment of Oral Implantology, School of Dentistry, Osaka Dental University, 8-1 Kuzuhahanazonocho, Hirakata 573-1121, Japan<b>Background:</b> The combination of polynucleotides and hyaluronic acid with bovine bone grafts in maxillary sinus lift procedures appears to be a promising strategy to enhance bone regeneration. This study aimed to analyze implant osseointegration, bone repair and sinus mucosa integrity using Bio-Oss<sup>®</sup> and Hyaluronic Acid-Polynucleotide Gel (Regenfast<sup>®</sup>) in maxillary sinus augmentation in rabbits. <b>Methods:</b> Sinus floor elevation was performed in 12 rabbits, with one implant placed per sinus simultaneously. In the control group, sinuses were grafted with deproteinized bovine bone mineral (Bio-Oss<sup>®</sup>) alone; in the test group, Bio-Oss<sup>®</sup> was combined with Regenfast<sup>®</sup>. Two histological slides were obtained per sinus after 2 weeks (six animals) and 10 weeks (six animals): one from the grafted area alone (non-implant sites), and one from the implant site. Primary outcome variables included the percentage of newly formed bone, the extent of implant osseointegration, and the number of sinus mucosa perforations caused by contact with graft granules. <b>Results:</b> After 10 weeks of healing, the test group showed a significantly higher percentage of new bone formation (37.2 ± 6.7%) compared to the control group (26.8 ± 10.0%; <i>p</i> = 0.031); osseointegration extended to the implant apex in both groups; fewer sinus mucosa perforations were observed in the test group (<i>n</i> = 5) than in the control group (<i>n</i> = 14). <b>Conclusions:</b> The addition of Regenfast<sup>®</sup> to Bio-Oss<sup>®</sup> granules promoted enhanced bone regeneration within the elevated sinus area and was associated with a lower incidence of sinus membrane perforations compared to the use of Bio-Oss<sup>®</sup> alone.https://www.mdpi.com/2304-6767/13/7/293animal studybone healinghistologyosseointegrationdental implantssinus augmentation |
| spellingShingle | Hiroyuki Omori Daniele Botticelli Erick Ricardo Silva Samuel Porfirio Xavier Sérgio Luis Scombatti de Souza Kaoru Kusano Shunsuke Baba Analysis of Implant Osseointegration, Bone Repair, and Sinus Mucosa Integrity Using Bio-Oss<sup>®</sup> and Hyaluronic Acid-Polynucleotide Gel (Regenfast<sup>®</sup>) in Maxillary Sinus Augmentation in Rabbits Dentistry Journal animal study bone healing histology osseointegration dental implants sinus augmentation |
| title | Analysis of Implant Osseointegration, Bone Repair, and Sinus Mucosa Integrity Using Bio-Oss<sup>®</sup> and Hyaluronic Acid-Polynucleotide Gel (Regenfast<sup>®</sup>) in Maxillary Sinus Augmentation in Rabbits |
| title_full | Analysis of Implant Osseointegration, Bone Repair, and Sinus Mucosa Integrity Using Bio-Oss<sup>®</sup> and Hyaluronic Acid-Polynucleotide Gel (Regenfast<sup>®</sup>) in Maxillary Sinus Augmentation in Rabbits |
| title_fullStr | Analysis of Implant Osseointegration, Bone Repair, and Sinus Mucosa Integrity Using Bio-Oss<sup>®</sup> and Hyaluronic Acid-Polynucleotide Gel (Regenfast<sup>®</sup>) in Maxillary Sinus Augmentation in Rabbits |
| title_full_unstemmed | Analysis of Implant Osseointegration, Bone Repair, and Sinus Mucosa Integrity Using Bio-Oss<sup>®</sup> and Hyaluronic Acid-Polynucleotide Gel (Regenfast<sup>®</sup>) in Maxillary Sinus Augmentation in Rabbits |
| title_short | Analysis of Implant Osseointegration, Bone Repair, and Sinus Mucosa Integrity Using Bio-Oss<sup>®</sup> and Hyaluronic Acid-Polynucleotide Gel (Regenfast<sup>®</sup>) in Maxillary Sinus Augmentation in Rabbits |
| title_sort | analysis of implant osseointegration bone repair and sinus mucosa integrity using bio oss sup r sup and hyaluronic acid polynucleotide gel regenfast sup r sup in maxillary sinus augmentation in rabbits |
| topic | animal study bone healing histology osseointegration dental implants sinus augmentation |
| url | https://www.mdpi.com/2304-6767/13/7/293 |
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