Calcium pyrophosphate crystal deposition disease as a risk factor for cardiovascular diseases
Calcium pyrophosphate crystal deposition disease (CPPD) is an inflammatory joint disease associated with abnormal accumulation of inorganic pyrophosphate. CPPD is frequently associated with metabolic disorders, such as hyperparathyroidism, hemochromatosis, hypomagnesemia, and hyperphosphatasia. It i...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2020-02-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2846 |
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| author | A. M. Novikova |
| author_facet | A. M. Novikova |
| author_sort | A. M. Novikova |
| collection | DOAJ |
| description | Calcium pyrophosphate crystal deposition disease (CPPD) is an inflammatory joint disease associated with abnormal accumulation of inorganic pyrophosphate. CPPD is frequently associated with metabolic disorders, such as hyperparathyroidism, hemochromatosis, hypomagnesemia, and hyperphosphatasia. It is important that pathological calcification can develop in both the joints and vessel wall. It is assumed that the deposition of calcifications in the endothelium, the crystal-induced chronic inflammation characteristic of CPPD, and its accompanying oxidative stress, as well as metabolic disorders that are a cause of secondary CPPD, can significantly increase the risk of cardiovascular diseases. |
| format | Article |
| id | doaj-art-6c25da37a26348d2ba4142a06f1be16b |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2020-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-6c25da37a26348d2ba4142a06f1be16b2025-08-20T02:55:20ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922020-02-01581808610.14412/1995-4484-2020-80-862580Calcium pyrophosphate crystal deposition disease as a risk factor for cardiovascular diseasesA. M. Novikova0V.A. Nasonova Research Institute of RheumatologyCalcium pyrophosphate crystal deposition disease (CPPD) is an inflammatory joint disease associated with abnormal accumulation of inorganic pyrophosphate. CPPD is frequently associated with metabolic disorders, such as hyperparathyroidism, hemochromatosis, hypomagnesemia, and hyperphosphatasia. It is important that pathological calcification can develop in both the joints and vessel wall. It is assumed that the deposition of calcifications in the endothelium, the crystal-induced chronic inflammation characteristic of CPPD, and its accompanying oxidative stress, as well as metabolic disorders that are a cause of secondary CPPD, can significantly increase the risk of cardiovascular diseases.https://rsp.mediar-press.net/rsp/article/view/2846calcium pyrophosphate crystal deposition diseasechondrocalcinosiscalcium pyrophosphate crystalscardiovascular diseasesinflammation |
| spellingShingle | A. M. Novikova Calcium pyrophosphate crystal deposition disease as a risk factor for cardiovascular diseases Научно-практическая ревматология calcium pyrophosphate crystal deposition disease chondrocalcinosis calcium pyrophosphate crystals cardiovascular diseases inflammation |
| title | Calcium pyrophosphate crystal deposition disease as a risk factor for cardiovascular diseases |
| title_full | Calcium pyrophosphate crystal deposition disease as a risk factor for cardiovascular diseases |
| title_fullStr | Calcium pyrophosphate crystal deposition disease as a risk factor for cardiovascular diseases |
| title_full_unstemmed | Calcium pyrophosphate crystal deposition disease as a risk factor for cardiovascular diseases |
| title_short | Calcium pyrophosphate crystal deposition disease as a risk factor for cardiovascular diseases |
| title_sort | calcium pyrophosphate crystal deposition disease as a risk factor for cardiovascular diseases |
| topic | calcium pyrophosphate crystal deposition disease chondrocalcinosis calcium pyrophosphate crystals cardiovascular diseases inflammation |
| url | https://rsp.mediar-press.net/rsp/article/view/2846 |
| work_keys_str_mv | AT amnovikova calciumpyrophosphatecrystaldepositiondiseaseasariskfactorforcardiovasculardiseases |