Human bocavirus-1 infection in hospitalized pediatric patients with acute respiratory tract infections
ABSTRACT Human bocavirus-1 (HBoV1) is an emerging viral pathogen associated with acute respiratory tract infections (ARTIs) in pediatric populations. This study aimed to evaluate the infection status and clinical characteristics of HBoV1 among hospitalized children suffering from ARTIs. A cohort of...
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| Language: | English |
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American Society for Microbiology
2025-04-01
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| Series: | Microbiology Spectrum |
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| Online Access: | https://journals.asm.org/doi/10.1128/spectrum.02985-24 |
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| author | Jie Tan Ziyin Huang Wenting Tang Guangbing Liu Peiqun Li Jiaqi Wen Lishai Mo Chenglan Yan Zhao Dang Huiping Huang Qifei Li Chunyun Fu |
| author_facet | Jie Tan Ziyin Huang Wenting Tang Guangbing Liu Peiqun Li Jiaqi Wen Lishai Mo Chenglan Yan Zhao Dang Huiping Huang Qifei Li Chunyun Fu |
| author_sort | Jie Tan |
| collection | DOAJ |
| description | ABSTRACT Human bocavirus-1 (HBoV1) is an emerging viral pathogen associated with acute respiratory tract infections (ARTIs) in pediatric populations. This study aimed to evaluate the infection status and clinical characteristics of HBoV1 among hospitalized children suffering from ARTIs. A cohort of 5,021 pediatric patients with respiratory infections was analyzed using targeted next-generation sequencing to identify HBoV1 and other co-existing respiratory pathogens. Results indicated a detection rate of HBoV1 of 8.48%, predominantly among infants under 24 months, with a higher prevalence observed in males. Among the 426 children with HBoV1 detected, there were 17 cases (4%) of single HBoV1 infection, and 409 cases (96%) were co-infected with HBoV1 and other pathogens. The predominant infection pattern was HBoV1-bacteria-virus co-infection (155 cases). A total of 48 other pathogens were detected in children with HBoV1 co-infections, with rhinovirus and human herpesvirus being the most common. The median hospitalization duration for the children with HBoV1 was 8 days, and 16.26% required ICU admission for monitoring. The study offers a comprehensive analysis of the distribution of co-infecting pathogens, clinical features, and outcomes in hospitalized children with HBoV one infection.IMPORTANCEThere is currently a poor understanding of the characteristics and clinical manifestations of human bocavirus-1 (HBoV1) infection. In the past decade, few studies have thoroughly analyzed co-infecting pathogens, such as viruses, bacteria, and fungi and their patterns in relation to HBoV1. This study utilizes targeted next-generation sequencing (tNGS) technology to identify HBoV1 and other common respiratory pathogens in 5,021 hospitalized children suffering from respiratory infections in the Guangxi region. It offers a detailed analysis of the distribution of co-infecting pathogens, infection patterns, laboratory findings, clinical manifestations, imaging features, complications, and prognoses related to HBoV1 infection in this population. The study highlights the high co-infection rates associated with HBoV1 and offers important insights for diagnosing, treating, and managing children with HBoV1 infection. |
| format | Article |
| id | doaj-art-6c1f8754c8f74368a1e0ada50fa5dd34 |
| institution | DOAJ |
| issn | 2165-0497 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | Microbiology Spectrum |
| spelling | doaj-art-6c1f8754c8f74368a1e0ada50fa5dd342025-08-20T02:53:43ZengAmerican Society for MicrobiologyMicrobiology Spectrum2165-04972025-04-0113410.1128/spectrum.02985-24Human bocavirus-1 infection in hospitalized pediatric patients with acute respiratory tract infectionsJie Tan0Ziyin Huang1Wenting Tang2Guangbing Liu3Peiqun Li4Jiaqi Wen5Lishai Mo6Chenglan Yan7Zhao Dang8Huiping Huang9Qifei Li10Chunyun Fu11Department of Pediatric Respiratory Medicine, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaMedical Science Laboratory, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaMedical Science Laboratory, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Pediatric Respiratory Medicine, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaMedical Science Laboratory, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaMedical Science Laboratory, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaMedical Science Laboratory, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaMedical Science Laboratory, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaMedical Science Laboratory, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Pediatric Respiratory Medicine, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDivision of Neonatology, University of Miami Miller School of Medicine and Holtz Children's Hospital, Jackson Health System, Miami, Florida, USAMedical Science Laboratory, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaABSTRACT Human bocavirus-1 (HBoV1) is an emerging viral pathogen associated with acute respiratory tract infections (ARTIs) in pediatric populations. This study aimed to evaluate the infection status and clinical characteristics of HBoV1 among hospitalized children suffering from ARTIs. A cohort of 5,021 pediatric patients with respiratory infections was analyzed using targeted next-generation sequencing to identify HBoV1 and other co-existing respiratory pathogens. Results indicated a detection rate of HBoV1 of 8.48%, predominantly among infants under 24 months, with a higher prevalence observed in males. Among the 426 children with HBoV1 detected, there were 17 cases (4%) of single HBoV1 infection, and 409 cases (96%) were co-infected with HBoV1 and other pathogens. The predominant infection pattern was HBoV1-bacteria-virus co-infection (155 cases). A total of 48 other pathogens were detected in children with HBoV1 co-infections, with rhinovirus and human herpesvirus being the most common. The median hospitalization duration for the children with HBoV1 was 8 days, and 16.26% required ICU admission for monitoring. The study offers a comprehensive analysis of the distribution of co-infecting pathogens, clinical features, and outcomes in hospitalized children with HBoV one infection.IMPORTANCEThere is currently a poor understanding of the characteristics and clinical manifestations of human bocavirus-1 (HBoV1) infection. In the past decade, few studies have thoroughly analyzed co-infecting pathogens, such as viruses, bacteria, and fungi and their patterns in relation to HBoV1. This study utilizes targeted next-generation sequencing (tNGS) technology to identify HBoV1 and other common respiratory pathogens in 5,021 hospitalized children suffering from respiratory infections in the Guangxi region. It offers a detailed analysis of the distribution of co-infecting pathogens, infection patterns, laboratory findings, clinical manifestations, imaging features, complications, and prognoses related to HBoV1 infection in this population. The study highlights the high co-infection rates associated with HBoV1 and offers important insights for diagnosing, treating, and managing children with HBoV1 infection.https://journals.asm.org/doi/10.1128/spectrum.02985-24human-bocaviruspathogensco-infectionspediatric patientstNGS |
| spellingShingle | Jie Tan Ziyin Huang Wenting Tang Guangbing Liu Peiqun Li Jiaqi Wen Lishai Mo Chenglan Yan Zhao Dang Huiping Huang Qifei Li Chunyun Fu Human bocavirus-1 infection in hospitalized pediatric patients with acute respiratory tract infections Microbiology Spectrum human-bocavirus pathogens co-infections pediatric patients tNGS |
| title | Human bocavirus-1 infection in hospitalized pediatric patients with acute respiratory tract infections |
| title_full | Human bocavirus-1 infection in hospitalized pediatric patients with acute respiratory tract infections |
| title_fullStr | Human bocavirus-1 infection in hospitalized pediatric patients with acute respiratory tract infections |
| title_full_unstemmed | Human bocavirus-1 infection in hospitalized pediatric patients with acute respiratory tract infections |
| title_short | Human bocavirus-1 infection in hospitalized pediatric patients with acute respiratory tract infections |
| title_sort | human bocavirus 1 infection in hospitalized pediatric patients with acute respiratory tract infections |
| topic | human-bocavirus pathogens co-infections pediatric patients tNGS |
| url | https://journals.asm.org/doi/10.1128/spectrum.02985-24 |
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