Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis
IntroductionNon-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide. Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, with high morbidity and mortality. The rapidly increasing incidence of NAFLD is becoming an essential p...
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Frontiers Media S.A.
2024-11-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1462513/full |
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| author | Qinghua Peng Qinghua Peng Xiaoning Zhu Xiaoning Zhu Xiaoning Zhu Yuanyuan Jiang Yuanyuan Jiang Mengyun Peng Mengyun Peng Ding Zheng Ding Zheng Xiaodong Wang Xiaodong Wang Yoke Kqueen Cheah Yoke Kqueen Cheah Jing Wang Jing Wang |
| author_facet | Qinghua Peng Qinghua Peng Xiaoning Zhu Xiaoning Zhu Xiaoning Zhu Yuanyuan Jiang Yuanyuan Jiang Mengyun Peng Mengyun Peng Ding Zheng Ding Zheng Xiaodong Wang Xiaodong Wang Yoke Kqueen Cheah Yoke Kqueen Cheah Jing Wang Jing Wang |
| author_sort | Qinghua Peng |
| collection | DOAJ |
| description | IntroductionNon-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide. Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, with high morbidity and mortality. The rapidly increasing incidence of NAFLD is becoming an essential precursor of HCC globally. MicroRNAs (miRNAs) are involved in the progression of NAFLD and HCC.MethodPotential miRNAs associated with NAFLD in HCC tumorigenesis were identified through a systematic review, and their roles were evaluated by data mining analysis. The biological function of the potential miRNA and its target genes in NAFLD and HCC were evaluated by bioinformatic analysis.ResultMIR122 was identified as the potential miRNA associated with NAFLD and HCC. Then, MIR122 expression was significantly lower in HCC patients, and higher MIR122 levels were associated with significantly better overall survival. Next, the biological functions of MIR122 and target genes were predicted to be involved in inflammation, fibrosis, cell proliferation, invasion, metastasis, and apoptosis. In particular, the FOXO signaling pathway may regulate the above biological functions.ConclusionMIR122 was suggested to be involved in progressing from NAFLD to HCC through the PI3K/AKT/FOXO pathway.Systematic review registrationPROSPERO, identifier: CRD 42024517940. |
| format | Article |
| id | doaj-art-6c1dcd63613e4a2bb2d8d1ce6f1fa68e |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-6c1dcd63613e4a2bb2d8d1ce6f1fa68e2024-11-15T04:52:38ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-11-011110.3389/fmed.2024.14625131462513Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysisQinghua Peng0Qinghua Peng1Xiaoning Zhu2Xiaoning Zhu3Xiaoning Zhu4Yuanyuan Jiang5Yuanyuan Jiang6Mengyun Peng7Mengyun Peng8Ding Zheng9Ding Zheng10Xiaodong Wang11Xiaodong Wang12Yoke Kqueen Cheah13Yoke Kqueen Cheah14Jing Wang15Jing Wang16Hepatobiliary Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Traditional Chinese Medicine of Liver Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaHepatobiliary Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Traditional Chinese Medicine of Liver Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, MalaysiaHepatobiliary Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Traditional Chinese Medicine of Liver Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaHepatobiliary Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Traditional Chinese Medicine of Liver Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaHepatobiliary Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Traditional Chinese Medicine of Liver Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaHepatobiliary Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Traditional Chinese Medicine of Liver Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, MalaysiaUPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor, MalaysiaHepatobiliary Department, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaSichuan Clinical Research Center for Traditional Chinese Medicine of Liver Diseases, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, ChinaIntroductionNon-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide. Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, with high morbidity and mortality. The rapidly increasing incidence of NAFLD is becoming an essential precursor of HCC globally. MicroRNAs (miRNAs) are involved in the progression of NAFLD and HCC.MethodPotential miRNAs associated with NAFLD in HCC tumorigenesis were identified through a systematic review, and their roles were evaluated by data mining analysis. The biological function of the potential miRNA and its target genes in NAFLD and HCC were evaluated by bioinformatic analysis.ResultMIR122 was identified as the potential miRNA associated with NAFLD and HCC. Then, MIR122 expression was significantly lower in HCC patients, and higher MIR122 levels were associated with significantly better overall survival. Next, the biological functions of MIR122 and target genes were predicted to be involved in inflammation, fibrosis, cell proliferation, invasion, metastasis, and apoptosis. In particular, the FOXO signaling pathway may regulate the above biological functions.ConclusionMIR122 was suggested to be involved in progressing from NAFLD to HCC through the PI3K/AKT/FOXO pathway.Systematic review registrationPROSPERO, identifier: CRD 42024517940.https://www.frontiersin.org/articles/10.3389/fmed.2024.1462513/fullnonalcoholic fatty liver diseasehepatocellular carcinomamicroRNAsbiological functionssignaling pathwaysystematic review |
| spellingShingle | Qinghua Peng Qinghua Peng Xiaoning Zhu Xiaoning Zhu Xiaoning Zhu Yuanyuan Jiang Yuanyuan Jiang Mengyun Peng Mengyun Peng Ding Zheng Ding Zheng Xiaodong Wang Xiaodong Wang Yoke Kqueen Cheah Yoke Kqueen Cheah Jing Wang Jing Wang Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis Frontiers in Medicine nonalcoholic fatty liver disease hepatocellular carcinoma microRNAs biological functions signaling pathway systematic review |
| title | Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| title_full | Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| title_fullStr | Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| title_full_unstemmed | Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| title_short | Evaluating the roles of microRNAs associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis: a systematic review and network analysis |
| title_sort | evaluating the roles of micrornas associated with nonalcoholic fatty liver disease in hepatocellular carcinoma tumorigenesis a systematic review and network analysis |
| topic | nonalcoholic fatty liver disease hepatocellular carcinoma microRNAs biological functions signaling pathway systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1462513/full |
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