Dabigatran and warfarin in nonvalvular atrial fibrillation or atrial flutter in outpatient clinic practice in Brazil
ABSTRACT Objectives: To compare warfarin and dabigatran for thromboembolic event prevention in patients with nonvalvular atrial fibrillation or atrial flutter. Methods: This was a retrospective cohort of participants with nonvalvular atrial fibrillation or atrial flutter using either warfarin or d...
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| Series: | Arquivos de Neuro-Psiquiatria |
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| author | Jean Michell Correia Monteiro Daniel Lordelo San-Martin Beatriz Carneiro Gondim Silva Ian Felipe Barbosa Souza Jamary Oliveira Filho Pedro Jesus |
| author_facet | Jean Michell Correia Monteiro Daniel Lordelo San-Martin Beatriz Carneiro Gondim Silva Ian Felipe Barbosa Souza Jamary Oliveira Filho Pedro Jesus |
| author_sort | Jean Michell Correia Monteiro |
| collection | DOAJ |
| description | ABSTRACT Objectives: To compare warfarin and dabigatran for thromboembolic event prevention in patients with nonvalvular atrial fibrillation or atrial flutter. Methods: This was a retrospective cohort of participants with nonvalvular atrial fibrillation or atrial flutter using either warfarin or dabigatran in a reference center in Brazil. Results: There were 112 patients (mean age 65.5 years), with 55.3% using warfarin. The median duration of follow-up was 1.9 years for warfarin and 1.6 years for dabigatran (p = 0.167). Warfarin patients had a higher median of medical appointments per year (8.3 [6.8-10.4] vs 3.1 [2.3-4.2], p < 0.001) and the frequency of minor bleeding was more than four times higher (17.7% vs 4.0%, p = 0.035). Among patients with prior stroke, those using warfarin had 2.6 times more medical appointments for person-years of follow-up (8.5 vs 3.3). There was no major bleeding or embolic event during follow-up period. Conclusion: The dabigatran group had a lower frequency of minor bleeding and number of medical appointments than the warfarin group, without more embolic events or major bleeding. |
| format | Article |
| id | doaj-art-6c1cd9858f004ee4be8c6088da34ea4b |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-6c1cd9858f004ee4be8c6088da34ea4b2025-08-20T03:33:46ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-4227772808310.1590/0004-282x20190005S0004-282X2019000200080Dabigatran and warfarin in nonvalvular atrial fibrillation or atrial flutter in outpatient clinic practice in BrazilJean Michell Correia MonteiroDaniel Lordelo San-MartinBeatriz Carneiro Gondim SilvaIan Felipe Barbosa SouzaJamary Oliveira FilhoPedro JesusABSTRACT Objectives: To compare warfarin and dabigatran for thromboembolic event prevention in patients with nonvalvular atrial fibrillation or atrial flutter. Methods: This was a retrospective cohort of participants with nonvalvular atrial fibrillation or atrial flutter using either warfarin or dabigatran in a reference center in Brazil. Results: There were 112 patients (mean age 65.5 years), with 55.3% using warfarin. The median duration of follow-up was 1.9 years for warfarin and 1.6 years for dabigatran (p = 0.167). Warfarin patients had a higher median of medical appointments per year (8.3 [6.8-10.4] vs 3.1 [2.3-4.2], p < 0.001) and the frequency of minor bleeding was more than four times higher (17.7% vs 4.0%, p = 0.035). Among patients with prior stroke, those using warfarin had 2.6 times more medical appointments for person-years of follow-up (8.5 vs 3.3). There was no major bleeding or embolic event during follow-up period. Conclusion: The dabigatran group had a lower frequency of minor bleeding and number of medical appointments than the warfarin group, without more embolic events or major bleeding.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019000200080&lng=en&tlng=enDabigatranavarfarinafibrilação atrialflutter atrialacidente vascular cerebral |
| spellingShingle | Jean Michell Correia Monteiro Daniel Lordelo San-Martin Beatriz Carneiro Gondim Silva Ian Felipe Barbosa Souza Jamary Oliveira Filho Pedro Jesus Dabigatran and warfarin in nonvalvular atrial fibrillation or atrial flutter in outpatient clinic practice in Brazil Arquivos de Neuro-Psiquiatria Dabigatrana varfarina fibrilação atrial flutter atrial acidente vascular cerebral |
| title | Dabigatran and warfarin in nonvalvular atrial fibrillation or atrial flutter in outpatient clinic practice in Brazil |
| title_full | Dabigatran and warfarin in nonvalvular atrial fibrillation or atrial flutter in outpatient clinic practice in Brazil |
| title_fullStr | Dabigatran and warfarin in nonvalvular atrial fibrillation or atrial flutter in outpatient clinic practice in Brazil |
| title_full_unstemmed | Dabigatran and warfarin in nonvalvular atrial fibrillation or atrial flutter in outpatient clinic practice in Brazil |
| title_short | Dabigatran and warfarin in nonvalvular atrial fibrillation or atrial flutter in outpatient clinic practice in Brazil |
| title_sort | dabigatran and warfarin in nonvalvular atrial fibrillation or atrial flutter in outpatient clinic practice in brazil |
| topic | Dabigatrana varfarina fibrilação atrial flutter atrial acidente vascular cerebral |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019000200080&lng=en&tlng=en |
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