The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics
Purpose. To evaluate the associations between metformin, insulin, statins, and levothyroxine and breast cancer characteristics and outcome. Methods. Retrospective chart review of patients treated in our institute for early estrogen receptor (ER) positive, human epidermal growth factor receptor 2 neg...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/4658469 |
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| author | Hadar Goldvaser Shulamith Rizel Daniel Hendler Victoria Neiman Daniel Shepshelovich Tzippy Shochat Aaron Sulkes Baruch Brenner Rinat Yerushalmi |
| author_facet | Hadar Goldvaser Shulamith Rizel Daniel Hendler Victoria Neiman Daniel Shepshelovich Tzippy Shochat Aaron Sulkes Baruch Brenner Rinat Yerushalmi |
| author_sort | Hadar Goldvaser |
| collection | DOAJ |
| description | Purpose. To evaluate the associations between metformin, insulin, statins, and levothyroxine and breast cancer characteristics and outcome. Methods. Retrospective chart review of patients treated in our institute for early estrogen receptor (ER) positive, human epidermal growth factor receptor 2 negative breast cancer, whose tumors were sent to Oncotype DX (ODX) analysis. Patients were grouped according to medications usage during the time of breast cancer diagnosis. Each group was compared to the rest of the study population. Results. The study cohort included 671 patients. Sixty (9.1%) patients were treated with metformin, 9 (1.4%) with insulin, 208 (31.7%) with statins, and 62 (9.4%) with levothyroxine. Patients treated with metformin had more intense ER stain (p=0.032) and a lower ODX recurrence score (RS) (p=0.035). Diagnosis of diabetes mellitus was also associated with lower ODX RS (p=0.014). Insulin usage was associated with a higher rate of angiolymphatic invasion (p=0.041), but lower Ki67% (p=0.017). Levothyroxine usage was associated with different histological subtype distribution (p=0.02). Extended levothyroxine usage was associated with lower ODX RS (p=0.005). Statin usage had no impact on tumor characteristics. Outcome was comparable in the studied subgroups. Conclusions. Common medications for metabolic disorders might be associated with breast cancer characteristics. |
| format | Article |
| id | doaj-art-6c1bb93aef584d3cb6e9008b9026dfd9 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6c1bb93aef584d3cb6e9008b9026dfd92025-08-20T03:33:46ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/46584694658469The Association between Treatment for Metabolic Disorders and Breast Cancer CharacteristicsHadar Goldvaser0Shulamith Rizel1Daniel Hendler2Victoria Neiman3Daniel Shepshelovich4Tzippy Shochat5Aaron Sulkes6Baruch Brenner7Rinat Yerushalmi8Institute of Oncology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St., Petah Tikva, IsraelInstitute of Oncology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St., Petah Tikva, IsraelInstitute of Oncology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St., Petah Tikva, IsraelInstitute of Oncology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St., Petah Tikva, IsraelSackler Faculty of Medicine, Tel Aviv University, P.O. Box 39040, Tel Aviv, IsraelStatistical Consulting Unit, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St., Petah Tikva, IsraelInstitute of Oncology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St., Petah Tikva, IsraelInstitute of Oncology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St., Petah Tikva, IsraelInstitute of Oncology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski St., Petah Tikva, IsraelPurpose. To evaluate the associations between metformin, insulin, statins, and levothyroxine and breast cancer characteristics and outcome. Methods. Retrospective chart review of patients treated in our institute for early estrogen receptor (ER) positive, human epidermal growth factor receptor 2 negative breast cancer, whose tumors were sent to Oncotype DX (ODX) analysis. Patients were grouped according to medications usage during the time of breast cancer diagnosis. Each group was compared to the rest of the study population. Results. The study cohort included 671 patients. Sixty (9.1%) patients were treated with metformin, 9 (1.4%) with insulin, 208 (31.7%) with statins, and 62 (9.4%) with levothyroxine. Patients treated with metformin had more intense ER stain (p=0.032) and a lower ODX recurrence score (RS) (p=0.035). Diagnosis of diabetes mellitus was also associated with lower ODX RS (p=0.014). Insulin usage was associated with a higher rate of angiolymphatic invasion (p=0.041), but lower Ki67% (p=0.017). Levothyroxine usage was associated with different histological subtype distribution (p=0.02). Extended levothyroxine usage was associated with lower ODX RS (p=0.005). Statin usage had no impact on tumor characteristics. Outcome was comparable in the studied subgroups. Conclusions. Common medications for metabolic disorders might be associated with breast cancer characteristics.http://dx.doi.org/10.1155/2016/4658469 |
| spellingShingle | Hadar Goldvaser Shulamith Rizel Daniel Hendler Victoria Neiman Daniel Shepshelovich Tzippy Shochat Aaron Sulkes Baruch Brenner Rinat Yerushalmi The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics International Journal of Endocrinology |
| title | The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics |
| title_full | The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics |
| title_fullStr | The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics |
| title_full_unstemmed | The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics |
| title_short | The Association between Treatment for Metabolic Disorders and Breast Cancer Characteristics |
| title_sort | association between treatment for metabolic disorders and breast cancer characteristics |
| url | http://dx.doi.org/10.1155/2016/4658469 |
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