Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease
Introduction. Patients with Parkinson’s disease (PD) showed reduced myocardial 123I-MIBG uptake, which may affect autonomic regulation. We investigated correlation between MIBC accumulation and cardiovascular autonomic function in PD. Methods. We performed myocardial MIBG scintigraphy, heart rate va...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/805351 |
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| author | Akira Katagiri Masato Asahina Nobuyuki Araki Anupama Poudel Yoshikatsu Fujinuma Yoshitaka Yamanaka Satoshi Kuwabara |
| author_facet | Akira Katagiri Masato Asahina Nobuyuki Araki Anupama Poudel Yoshikatsu Fujinuma Yoshitaka Yamanaka Satoshi Kuwabara |
| author_sort | Akira Katagiri |
| collection | DOAJ |
| description | Introduction. Patients with Parkinson’s disease (PD) showed reduced myocardial 123I-MIBG uptake, which may affect autonomic regulation. We investigated correlation between MIBC accumulation and cardiovascular autonomic function in PD. Methods. We performed myocardial MIBG scintigraphy, heart rate variability (HRV) analysis, and the head-up tilt test (HUT) in 50 PD patients (66.4±7.8 years; duration 5.5±5.9 years). Autonomic function tests were also performed in 50 healthy controls (66.5±8.9 years). As HRV parameters, a high-frequency power (HF, 0.15–0.4 Hz), a low-frequency power (LF, 0.04–0.15 Hz), and LF/HF ratio were used. Results. Our PD patients had a significant reduction in LF and HF compared with the controls (P=0.005 and P=0.01). In HUT, systolic and diastolic blood pressure falls in the PD group were significantly greater than those in the controls (P=0.02 and P=0.02). The washout rate of MIBG was negatively correlated with blood pressure changes during HUT. Conclusion. Our PD patients showed reduced HRV, blood pressure dysregulation, and reduced MIBG accumulation, which was correlated with blood pressure dysregulation. Orthostatic hypotension in PD may be mainly caused by sympathetic postganglionic degeneration. |
| format | Article |
| id | doaj-art-6c1b3d2c411c4e52aaa15470aa955f63 |
| institution | OA Journals |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-6c1b3d2c411c4e52aaa15470aa955f632025-08-20T02:06:08ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/805351805351Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s DiseaseAkira Katagiri0Masato Asahina1Nobuyuki Araki2Anupama Poudel3Yoshikatsu Fujinuma4Yoshitaka Yamanaka5Satoshi Kuwabara6Department of Neurology, Chiba University School of Medicine, Chiba 260-8670, JapanDepartment of Neurology, Chiba University School of Medicine, Chiba 260-8670, JapanDepartment of Neurology, Chiba University School of Medicine, Chiba 260-8670, JapanDepartment of Neurology, Chiba University School of Medicine, Chiba 260-8670, JapanDepartment of Neurology, Chiba University School of Medicine, Chiba 260-8670, JapanDepartment of Neurology, Chiba University School of Medicine, Chiba 260-8670, JapanDepartment of Neurology, Chiba University School of Medicine, Chiba 260-8670, JapanIntroduction. Patients with Parkinson’s disease (PD) showed reduced myocardial 123I-MIBG uptake, which may affect autonomic regulation. We investigated correlation between MIBC accumulation and cardiovascular autonomic function in PD. Methods. We performed myocardial MIBG scintigraphy, heart rate variability (HRV) analysis, and the head-up tilt test (HUT) in 50 PD patients (66.4±7.8 years; duration 5.5±5.9 years). Autonomic function tests were also performed in 50 healthy controls (66.5±8.9 years). As HRV parameters, a high-frequency power (HF, 0.15–0.4 Hz), a low-frequency power (LF, 0.04–0.15 Hz), and LF/HF ratio were used. Results. Our PD patients had a significant reduction in LF and HF compared with the controls (P=0.005 and P=0.01). In HUT, systolic and diastolic blood pressure falls in the PD group were significantly greater than those in the controls (P=0.02 and P=0.02). The washout rate of MIBG was negatively correlated with blood pressure changes during HUT. Conclusion. Our PD patients showed reduced HRV, blood pressure dysregulation, and reduced MIBG accumulation, which was correlated with blood pressure dysregulation. Orthostatic hypotension in PD may be mainly caused by sympathetic postganglionic degeneration.http://dx.doi.org/10.1155/2015/805351 |
| spellingShingle | Akira Katagiri Masato Asahina Nobuyuki Araki Anupama Poudel Yoshikatsu Fujinuma Yoshitaka Yamanaka Satoshi Kuwabara Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease Parkinson's Disease |
| title | Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease |
| title_full | Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease |
| title_fullStr | Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease |
| title_full_unstemmed | Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease |
| title_short | Myocardial 123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease |
| title_sort | myocardial 123i mibg uptake and cardiovascular autonomic function in parkinson s disease |
| url | http://dx.doi.org/10.1155/2015/805351 |
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