Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021
<i>Background and Objectives</i>: Alzheimer’s disease and other dementias represent some of the leading public health concerns worldwide. This study aimed to assess the global burden of Alzheimer’s disease and other dementias attributable to high fasting plasma glucose in the last decade...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/60/11/1783 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850068283285307392 |
|---|---|
| author | Irena Ilic Vladimir Jakovljevic Ivana Zivanovic Macuzic Ana Ravic-Nikolic Milena Ilic Marija Sorak Vesna Milicic |
| author_facet | Irena Ilic Vladimir Jakovljevic Ivana Zivanovic Macuzic Ana Ravic-Nikolic Milena Ilic Marija Sorak Vesna Milicic |
| author_sort | Irena Ilic |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Alzheimer’s disease and other dementias represent some of the leading public health concerns worldwide. This study aimed to assess the global burden of Alzheimer’s disease and other dementias attributable to high fasting plasma glucose in the last decades. <i>Materials and Methods</i>: A descriptive epidemiological study was conducted. The Global Burden of Disease (GBD) study data about deaths and Disability-Adjusted Life Years (DALYs) were used. All figures were presented as age-standardized rates (ASRs). The average annual percent change (AAPC) was computed using the Joinpoint regression analysis. Also, age-period-cohort analysis was performed. <i>Results</i>: A total of 2 million deaths from Alzheimer’s disease and other dementias were reported worldwide in 2021, whereby the total number deaths from Alzheimer’s disease and other dementias attributable to high fasting plasma glucose was 290,032 (98,900 males and 191,132 females) in 2021. The highest ASRs of burden of Alzheimer’s disease and other dementias attributable to high fasting plasma glucose were found in Afghanistan, Iraq, Morocco, Qatar, and the United States of America, while the lowest ASRs were in Belarus and Mongolia. From 1990 to 2021, a significant increase (<i>p</i> < 0.001) was noted in ASRs of deaths and DALYs for Alzheimer’s disease and other dementias attributable to high fasting plasma glucose. Looking at the GBD regions, the trends in ASRs for mortality and for DALYs of Alzheimer’s disease and other dementias attributable to high fasting plasma glucose between 1990 and 2021 showed a growth 10-fold faster in High-income North America (AAPC = 2.0%, for both equally) and Central Asia (AAPC = 2.4% and AAPC = 2.5%, respectively) than in the region of High-income Asia Pacific (AAPC = 0.1% and AAPC = 0.2%, respectively). The relative risk of mortality and DALYs for Alzheimer’s disease and other dementias attributable to high fasting plasma glucose demonstrated statistically significant (<i>p</i> < 0.0001) period and cohort effects, and net drift and local drifts. <i>Conclusions</i>: This study showed an increase in the global burden of Alzheimer’s disease and other dementias attributable to high fasting plasma glucose in the last decades. Future successful entire-population strategies targeting high fasting plasma glucose may reduce the burden of a wide range of these diseases. |
| format | Article |
| id | doaj-art-6c169fd02f34410eac9c83b02ce67ef7 |
| institution | DOAJ |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-6c169fd02f34410eac9c83b02ce67ef72025-08-20T02:48:06ZengMDPI AGMedicina1010-660X1648-91442024-10-016011178310.3390/medicina60111783Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021Irena Ilic0Vladimir Jakovljevic1Ivana Zivanovic Macuzic2Ana Ravic-Nikolic3Milena Ilic4Marija Sorak5Vesna Milicic6Faculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Anatomy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Dermatovenerology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Epidemiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Gynecology and Obstetrics, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Dermatovenerology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia<i>Background and Objectives</i>: Alzheimer’s disease and other dementias represent some of the leading public health concerns worldwide. This study aimed to assess the global burden of Alzheimer’s disease and other dementias attributable to high fasting plasma glucose in the last decades. <i>Materials and Methods</i>: A descriptive epidemiological study was conducted. The Global Burden of Disease (GBD) study data about deaths and Disability-Adjusted Life Years (DALYs) were used. All figures were presented as age-standardized rates (ASRs). The average annual percent change (AAPC) was computed using the Joinpoint regression analysis. Also, age-period-cohort analysis was performed. <i>Results</i>: A total of 2 million deaths from Alzheimer’s disease and other dementias were reported worldwide in 2021, whereby the total number deaths from Alzheimer’s disease and other dementias attributable to high fasting plasma glucose was 290,032 (98,900 males and 191,132 females) in 2021. The highest ASRs of burden of Alzheimer’s disease and other dementias attributable to high fasting plasma glucose were found in Afghanistan, Iraq, Morocco, Qatar, and the United States of America, while the lowest ASRs were in Belarus and Mongolia. From 1990 to 2021, a significant increase (<i>p</i> < 0.001) was noted in ASRs of deaths and DALYs for Alzheimer’s disease and other dementias attributable to high fasting plasma glucose. Looking at the GBD regions, the trends in ASRs for mortality and for DALYs of Alzheimer’s disease and other dementias attributable to high fasting plasma glucose between 1990 and 2021 showed a growth 10-fold faster in High-income North America (AAPC = 2.0%, for both equally) and Central Asia (AAPC = 2.4% and AAPC = 2.5%, respectively) than in the region of High-income Asia Pacific (AAPC = 0.1% and AAPC = 0.2%, respectively). The relative risk of mortality and DALYs for Alzheimer’s disease and other dementias attributable to high fasting plasma glucose demonstrated statistically significant (<i>p</i> < 0.0001) period and cohort effects, and net drift and local drifts. <i>Conclusions</i>: This study showed an increase in the global burden of Alzheimer’s disease and other dementias attributable to high fasting plasma glucose in the last decades. Future successful entire-population strategies targeting high fasting plasma glucose may reduce the burden of a wide range of these diseases.https://www.mdpi.com/1648-9144/60/11/1783Alzheimer’s diseasehigh fasting plasma glucoseburdentrends |
| spellingShingle | Irena Ilic Vladimir Jakovljevic Ivana Zivanovic Macuzic Ana Ravic-Nikolic Milena Ilic Marija Sorak Vesna Milicic Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021 Medicina Alzheimer’s disease high fasting plasma glucose burden trends |
| title | Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021 |
| title_full | Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021 |
| title_fullStr | Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021 |
| title_full_unstemmed | Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021 |
| title_short | Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021 |
| title_sort | trends in global burden of alzheimer s disease and other dementias attributable to high fasting plasma glucose 1990 2021 |
| topic | Alzheimer’s disease high fasting plasma glucose burden trends |
| url | https://www.mdpi.com/1648-9144/60/11/1783 |
| work_keys_str_mv | AT irenailic trendsinglobalburdenofalzheimersdiseaseandotherdementiasattributabletohighfastingplasmaglucose19902021 AT vladimirjakovljevic trendsinglobalburdenofalzheimersdiseaseandotherdementiasattributabletohighfastingplasmaglucose19902021 AT ivanazivanovicmacuzic trendsinglobalburdenofalzheimersdiseaseandotherdementiasattributabletohighfastingplasmaglucose19902021 AT anaravicnikolic trendsinglobalburdenofalzheimersdiseaseandotherdementiasattributabletohighfastingplasmaglucose19902021 AT milenailic trendsinglobalburdenofalzheimersdiseaseandotherdementiasattributabletohighfastingplasmaglucose19902021 AT marijasorak trendsinglobalburdenofalzheimersdiseaseandotherdementiasattributabletohighfastingplasmaglucose19902021 AT vesnamilicic trendsinglobalburdenofalzheimersdiseaseandotherdementiasattributabletohighfastingplasmaglucose19902021 |