Toxicokinetics of Kava
Kava is traditionally consumed by South Pacific islanders as a drink and became popular in Western society as a supplement for anxiety and insomnia. Kava extracts are generally well tolerated, but reports of hepatotoxicity necessitated an international reappraisal of its safety. Hepatotoxicity can o...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2011/326724 |
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| _version_ | 1850222916372791296 |
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| author | Anthony Rowe Lillian Yuan Zhang Iqbal Ramzan |
| author_facet | Anthony Rowe Lillian Yuan Zhang Iqbal Ramzan |
| author_sort | Anthony Rowe |
| collection | DOAJ |
| description | Kava is traditionally consumed by South Pacific islanders as a drink and became popular in Western society as a supplement for anxiety and insomnia. Kava extracts are generally well tolerated, but reports of hepatotoxicity necessitated an international reappraisal of its safety. Hepatotoxicity can occur as an acute, severe form or a chronic, mild form. Inflammation appears to be involved in both forms and may result from activation of liver macrophages (Kupffer cells), either directly or via kava metabolites. Pharmacogenomics may influence the severity of this inflammatory response. |
| format | Article |
| id | doaj-art-6c151d032c554169ac784bea232a4df1 |
| institution | OA Journals |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-6c151d032c554169ac784bea232a4df12025-08-20T02:06:11ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422011-01-01201110.1155/2011/326724326724Toxicokinetics of KavaAnthony Rowe0Lillian Yuan Zhang1Iqbal Ramzan2Faculty of Pharmacy, University of Sydney, Bank Building (A15), Sydney, NSW 2006, AustraliaFaculty of Pharmacy, University of Sydney, Bank Building (A15), Sydney, NSW 2006, AustraliaFaculty of Pharmacy, University of Sydney, Bank Building (A15), Sydney, NSW 2006, AustraliaKava is traditionally consumed by South Pacific islanders as a drink and became popular in Western society as a supplement for anxiety and insomnia. Kava extracts are generally well tolerated, but reports of hepatotoxicity necessitated an international reappraisal of its safety. Hepatotoxicity can occur as an acute, severe form or a chronic, mild form. Inflammation appears to be involved in both forms and may result from activation of liver macrophages (Kupffer cells), either directly or via kava metabolites. Pharmacogenomics may influence the severity of this inflammatory response.http://dx.doi.org/10.1155/2011/326724 |
| spellingShingle | Anthony Rowe Lillian Yuan Zhang Iqbal Ramzan Toxicokinetics of Kava Advances in Pharmacological Sciences |
| title | Toxicokinetics of Kava |
| title_full | Toxicokinetics of Kava |
| title_fullStr | Toxicokinetics of Kava |
| title_full_unstemmed | Toxicokinetics of Kava |
| title_short | Toxicokinetics of Kava |
| title_sort | toxicokinetics of kava |
| url | http://dx.doi.org/10.1155/2011/326724 |
| work_keys_str_mv | AT anthonyrowe toxicokineticsofkava AT lillianyuanzhang toxicokineticsofkava AT iqbalramzan toxicokineticsofkava |