Sphingosine 1-phosphate in acute dengue infection.
<h4>Background</h4>Vascular leak is the hallmark of severe dengue infections and leads to complications such as shock and multi-organ failure. Although many mediators have been implicated in the vascular leak in dengue, the role of sphingosine 1-phosphate (S1P) has not been investigated....
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0113394 |
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| author | Laksiri Gomes Samitha Fernando Randika Heshan Fernando Nilanka Wickramasinghe Narangoda Liyanage Ajantha Shyamali Graham S Ogg Gathsaurie Neelika Malavige |
| author_facet | Laksiri Gomes Samitha Fernando Randika Heshan Fernando Nilanka Wickramasinghe Narangoda Liyanage Ajantha Shyamali Graham S Ogg Gathsaurie Neelika Malavige |
| author_sort | Laksiri Gomes |
| collection | DOAJ |
| description | <h4>Background</h4>Vascular leak is the hallmark of severe dengue infections and leads to complications such as shock and multi-organ failure. Although many mediators have been implicated in the vascular leak in dengue, the role of sphingosine 1-phosphate (S1P) has not been investigated.<h4>Metholodology/principal findings</h4>As S1P has been shown to be important in barrier integrity, we assessed the S1P levels in 28 patients with acute dengue and 12 healthy individuals. The S1P levels were significantly lower in patients with acute dengue (p = 0.002) and the levels in patients with grade IV dengue haemorrhagic fever (DHF) were significantly lower than those with dengue fever (p = 0.005). We then investigated the kinetics of S1P levels throughout the course of the illness in another 32 patients in serum samples obtained twice a day. We found that S1P levels were low throughout the course of illness and S1P levels were <0.5 µM in 12/23 patients with DHF when compared to 1/9 with DF.<h4>Conclusions/significance</h4>As S1P has shown to be important in the endothelial barrier integrity and increases transendothelial resistance, low levels of S1P in acute dengue infection are likely to contribute to increased vascular permeability. |
| format | Article |
| id | doaj-art-6c12473d79ae4efd8fdbba63ceb2ab04 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-6c12473d79ae4efd8fdbba63ceb2ab042025-08-20T03:10:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11339410.1371/journal.pone.0113394Sphingosine 1-phosphate in acute dengue infection.Laksiri GomesSamitha FernandoRandika Heshan FernandoNilanka WickramasingheNarangoda Liyanage Ajantha ShyamaliGraham S OggGathsaurie Neelika Malavige<h4>Background</h4>Vascular leak is the hallmark of severe dengue infections and leads to complications such as shock and multi-organ failure. Although many mediators have been implicated in the vascular leak in dengue, the role of sphingosine 1-phosphate (S1P) has not been investigated.<h4>Metholodology/principal findings</h4>As S1P has been shown to be important in barrier integrity, we assessed the S1P levels in 28 patients with acute dengue and 12 healthy individuals. The S1P levels were significantly lower in patients with acute dengue (p = 0.002) and the levels in patients with grade IV dengue haemorrhagic fever (DHF) were significantly lower than those with dengue fever (p = 0.005). We then investigated the kinetics of S1P levels throughout the course of the illness in another 32 patients in serum samples obtained twice a day. We found that S1P levels were low throughout the course of illness and S1P levels were <0.5 µM in 12/23 patients with DHF when compared to 1/9 with DF.<h4>Conclusions/significance</h4>As S1P has shown to be important in the endothelial barrier integrity and increases transendothelial resistance, low levels of S1P in acute dengue infection are likely to contribute to increased vascular permeability.https://doi.org/10.1371/journal.pone.0113394 |
| spellingShingle | Laksiri Gomes Samitha Fernando Randika Heshan Fernando Nilanka Wickramasinghe Narangoda Liyanage Ajantha Shyamali Graham S Ogg Gathsaurie Neelika Malavige Sphingosine 1-phosphate in acute dengue infection. PLoS ONE |
| title | Sphingosine 1-phosphate in acute dengue infection. |
| title_full | Sphingosine 1-phosphate in acute dengue infection. |
| title_fullStr | Sphingosine 1-phosphate in acute dengue infection. |
| title_full_unstemmed | Sphingosine 1-phosphate in acute dengue infection. |
| title_short | Sphingosine 1-phosphate in acute dengue infection. |
| title_sort | sphingosine 1 phosphate in acute dengue infection |
| url | https://doi.org/10.1371/journal.pone.0113394 |
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