Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus

Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus

Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) causes a severe respiratory disease in humans. The MERS-CoV spike (S) glycoprotein mediates viral entry into target cells. For this, MERS-CoV S engages the host cell protein dipeptidyl peptidase 4 (DPP4, CD26) and the interface between M...

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Bibliographic Details
Main Authors: Hannah Kleine-Weber, Simon Schroeder, Nadine Krüger, Alexander Prokscha, Hassan Y. Naim, Marcel A. Müller, Christian Drosten, Stefan Pöhlmann, Markus Hoffmann
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
Middle East respiratory syndrome coronavirus
spike glycoprotein
dipeptidyl peptidase 4
polymorphisms
receptor binding
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1713705
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