Long-term response to pimitespib in postoperative recurrent gastrointestinal stromal tumors with PDGFRA D842V mutation: a case report

Long-term response to pimitespib in postoperative recurrent gastrointestinal stromal tumors with PDGFRA D842V mutation: a case report

Abstract Background Exon 18 D842V, which is a point mutation from aspartic acid to valine at codon 842, is the most frequent mutation in Platelet-Derived Growth Factor Receptor alpha (PDGFRA)-mutated gastrointestinal stromal tumor (GIST). In the Japanese GIST guidelines, no standard systematic thera...

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Main Authors: Ryugo Teranishi, Tsuyoshi Takahashi, Yukinori Kurokawa, Takuro Saito, Kazuyoshi Yamamoto, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki
Format: Article
Language:English
Published: Japan Surgical Society 2023-04-01
Series:Surgical Case Reports
Subjects:
GIST
PDGFRA
exon18 D842V mutation
Pimitespib
Avapritinib
HSP90
Online Access:https://doi.org/10.1186/s40792-023-01637-4
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