Molecular and cellular mechanisms of adipogenesis
The main components of metabolic syndrome include insulin resistance, hypertriglyceridemia and arterial hypertension. Obesity is the cause of metabolic syndrome, mainly as a consequence of the endocrine function of adipose tissue. The volume of adipose tissue depends on the size of individual adipoc...
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| Language: | English |
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Endocrinology Research Centre
2015-06-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6824 |
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| author | Alexander Dmitrievich Egorov Dmitry Nikolaevich Penkov Vsevolod Arsen'evich Tkachuk |
| author_facet | Alexander Dmitrievich Egorov Dmitry Nikolaevich Penkov Vsevolod Arsen'evich Tkachuk |
| author_sort | Alexander Dmitrievich Egorov |
| collection | DOAJ |
| description | The main components of metabolic syndrome include insulin resistance, hypertriglyceridemia and arterial hypertension. Obesity is the cause of metabolic syndrome, mainly as a consequence of the endocrine function of adipose tissue. The volume of adipose tissue depends on the size of individual adipocytes and on their number. The number of adipocytes increases as a result of enhanced adipocyte differentiation. The transcriptional cascade that regulates this differentiation has been well studied. The major adipogenic transcription factor peroxisome proliferator-activated receptor gamma is a ligand-activated nuclear receptor with essential roles in adipogenesis. Its ligands are used to treat metabolic syndrome and type 2 diabetes mellitus. . The present article describes the basic molecular and cellular mechanisms of adipogenesis and discusses the impact of insulin, glucocorticoids, cyclic adenosine monophosphate-activating agents, nuclear receptors and transcription factors on the process of adipogenesis. New regulatory regions of the genome that are capable of binding multiple transcription factors are described, and the most promising drug targets for the treatment of metabolic syndrome and obesity, including the homeodomain proteins Pbx1 and Prep1, are discussed.. |
| format | Article |
| id | doaj-art-6c05b5cc8026490b897b25b3aea741fa |
| institution | Kabale University |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2015-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-6c05b5cc8026490b897b25b3aea741fa2025-08-20T03:47:53ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782015-06-01182121910.14341/DM2015212-196752Molecular and cellular mechanisms of adipogenesisAlexander Dmitrievich Egorov0Dmitry Nikolaevich Penkov1Vsevolod Arsen'evich Tkachuk2Lomonosov Moscow State University, MoscowRussian Cardiology Research and Production Complex, MoscowLomonosov Moscow State University, MoscowThe main components of metabolic syndrome include insulin resistance, hypertriglyceridemia and arterial hypertension. Obesity is the cause of metabolic syndrome, mainly as a consequence of the endocrine function of adipose tissue. The volume of adipose tissue depends on the size of individual adipocytes and on their number. The number of adipocytes increases as a result of enhanced adipocyte differentiation. The transcriptional cascade that regulates this differentiation has been well studied. The major adipogenic transcription factor peroxisome proliferator-activated receptor gamma is a ligand-activated nuclear receptor with essential roles in adipogenesis. Its ligands are used to treat metabolic syndrome and type 2 diabetes mellitus. . The present article describes the basic molecular and cellular mechanisms of adipogenesis and discusses the impact of insulin, glucocorticoids, cyclic adenosine monophosphate-activating agents, nuclear receptors and transcription factors on the process of adipogenesis. New regulatory regions of the genome that are capable of binding multiple transcription factors are described, and the most promising drug targets for the treatment of metabolic syndrome and obesity, including the homeodomain proteins Pbx1 and Prep1, are discussed..https://www.dia-endojournals.ru/jour/article/view/6824adipogenesistranscription factorstranscriptional activationppar?homeodomain proteins |
| spellingShingle | Alexander Dmitrievich Egorov Dmitry Nikolaevich Penkov Vsevolod Arsen'evich Tkachuk Molecular and cellular mechanisms of adipogenesis Сахарный диабет adipogenesis transcription factors transcriptional activation ppar? homeodomain proteins |
| title | Molecular and cellular mechanisms of adipogenesis |
| title_full | Molecular and cellular mechanisms of adipogenesis |
| title_fullStr | Molecular and cellular mechanisms of adipogenesis |
| title_full_unstemmed | Molecular and cellular mechanisms of adipogenesis |
| title_short | Molecular and cellular mechanisms of adipogenesis |
| title_sort | molecular and cellular mechanisms of adipogenesis |
| topic | adipogenesis transcription factors transcriptional activation ppar? homeodomain proteins |
| url | https://www.dia-endojournals.ru/jour/article/view/6824 |
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