A review on anti-cancer properties of quercetin in gastric cancer
This review paper focuses on the multifaceted roles and therapeutic potential of quercetin in gastric cancer (GC). Quercetin, a natural flavonoid compound abundant in dietary sources such as nuts, teas, vegetables, and herbs, has garnered significant attention due to its anticancer properties. Accum...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1563229/full |
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| author | Xiaoxia Xie Yan Wei |
| author_facet | Xiaoxia Xie Yan Wei |
| author_sort | Xiaoxia Xie |
| collection | DOAJ |
| description | This review paper focuses on the multifaceted roles and therapeutic potential of quercetin in gastric cancer (GC). Quercetin, a natural flavonoid compound abundant in dietary sources such as nuts, teas, vegetables, and herbs, has garnered significant attention due to its anticancer properties. Accumulated evidence demonstrates quercetin’s inhibitory effects against GC by targeting key pathways such as cell cycle regulation, fatty acid synthesis, and mitochondrial apoptosis, thereby exerting anti-proliferative and apoptotic strategies. Furthermore, quercetin effectively alleviates GC-related inflammation, optimizing the tumor microenvironment. Mechanistically, quercetin induces various forms of programmed cell death in GC cells, including ferroptosis, pyroptosis, and autophagy, through regulating specific molecular targets. Additionally, quercetin inhibits GC angiogenesis by downregulating vascular endothelial growth factor A (VEGF-A) and its receptor VEGFR-2 expression, and demonstrates anti-metastatic effects by modulating urokinase-type plasminogen activator (uPA) and its receptor (uPAR) function. As research delves deeper into the mechanisms of quercetin’s actions and its validation in clinical trials, its prospects as a novel therapeutic agent for GC become increasingly promising. Quercetin’s low toxicity and ability to synergize with other anticancer drugs make it a potential key component in comprehensive GC treatment strategies, significantly enhancing patient prognosis and quality of life. |
| format | Article |
| id | doaj-art-6c04358a16bb4bd68bbf055b8ae73483 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-6c04358a16bb4bd68bbf055b8ae734832025-08-20T03:53:46ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15632291563229A review on anti-cancer properties of quercetin in gastric cancerXiaoxia XieYan WeiThis review paper focuses on the multifaceted roles and therapeutic potential of quercetin in gastric cancer (GC). Quercetin, a natural flavonoid compound abundant in dietary sources such as nuts, teas, vegetables, and herbs, has garnered significant attention due to its anticancer properties. Accumulated evidence demonstrates quercetin’s inhibitory effects against GC by targeting key pathways such as cell cycle regulation, fatty acid synthesis, and mitochondrial apoptosis, thereby exerting anti-proliferative and apoptotic strategies. Furthermore, quercetin effectively alleviates GC-related inflammation, optimizing the tumor microenvironment. Mechanistically, quercetin induces various forms of programmed cell death in GC cells, including ferroptosis, pyroptosis, and autophagy, through regulating specific molecular targets. Additionally, quercetin inhibits GC angiogenesis by downregulating vascular endothelial growth factor A (VEGF-A) and its receptor VEGFR-2 expression, and demonstrates anti-metastatic effects by modulating urokinase-type plasminogen activator (uPA) and its receptor (uPAR) function. As research delves deeper into the mechanisms of quercetin’s actions and its validation in clinical trials, its prospects as a novel therapeutic agent for GC become increasingly promising. Quercetin’s low toxicity and ability to synergize with other anticancer drugs make it a potential key component in comprehensive GC treatment strategies, significantly enhancing patient prognosis and quality of life.https://www.frontiersin.org/articles/10.3389/fphar.2025.1563229/fullquercetingastric canceranti-proliferationcell deathanti-inflammatory |
| spellingShingle | Xiaoxia Xie Yan Wei A review on anti-cancer properties of quercetin in gastric cancer Frontiers in Pharmacology quercetin gastric cancer anti-proliferation cell death anti-inflammatory |
| title | A review on anti-cancer properties of quercetin in gastric cancer |
| title_full | A review on anti-cancer properties of quercetin in gastric cancer |
| title_fullStr | A review on anti-cancer properties of quercetin in gastric cancer |
| title_full_unstemmed | A review on anti-cancer properties of quercetin in gastric cancer |
| title_short | A review on anti-cancer properties of quercetin in gastric cancer |
| title_sort | review on anti cancer properties of quercetin in gastric cancer |
| topic | quercetin gastric cancer anti-proliferation cell death anti-inflammatory |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1563229/full |
| work_keys_str_mv | AT xiaoxiaxie areviewonanticancerpropertiesofquercetiningastriccancer AT yanwei areviewonanticancerpropertiesofquercetiningastriccancer AT xiaoxiaxie reviewonanticancerpropertiesofquercetiningastriccancer AT yanwei reviewonanticancerpropertiesofquercetiningastriccancer |