Roles of T Cells in the Pathogenesis of Autoimmune Diseases
γδ T cells are a minor population of T cells that express the TCR γδ chains, mainly distributed in the mucosal and epithelial tissue and accounting for less than 5% of the total T cells in the peripheral blood. By bridging innate and adaptive immunity, γδ T cells play important roles in the anti-inf...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/985753 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850222912214138880 |
|---|---|
| author | Dinglei Su Minning Shen Xia Li Lingyun Sun |
| author_facet | Dinglei Su Minning Shen Xia Li Lingyun Sun |
| author_sort | Dinglei Su |
| collection | DOAJ |
| description | γδ T cells are a minor population of T cells that express the TCR γδ chains, mainly distributed in the mucosal and epithelial tissue and accounting for less than 5% of the total T cells in the peripheral blood. By bridging innate and adaptive immunity, γδ T cells play important roles in the anti-infection, antitumor, and autoimmune responses. Previous research on γδ T cells was primarily concentrated on infectious diseases and tumors, whereas their functions in autoimmune diseases attracted much attention. In this paper, we summarized the various functions of
γδ T cells in two prototypical autoimmune connective tissue diseases, that is, SLE and RA, elaborating on their antigen-presenting capacity, secretion of proinflammatory cytokines, immunomodulatory effects, and auxiliary function for B cells, which contribute to overproduction of proinflammatory cytokines and pathogenic autoantibodies, ultimately leading to the onset of these autoimmune diseases. Elucidation of the roles of γδ T cells in autoimmune diseases is not only conducive to in-depth understanding of the pathogenesis of these diseases, but also beneficial in providing theoretical support for the development of γδ T-cell-targeted therapy. |
| format | Article |
| id | doaj-art-6bffe9f9330e4bb4aa09e7e861348d49 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-6bffe9f9330e4bb4aa09e7e861348d492025-08-20T02:06:11ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/985753985753Roles of T Cells in the Pathogenesis of Autoimmune DiseasesDinglei Su0Minning Shen1Xia Li2Lingyun Sun3Department of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaDepartment of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, ChinaDepartment of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaDepartment of Immunology and Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Chinaγδ T cells are a minor population of T cells that express the TCR γδ chains, mainly distributed in the mucosal and epithelial tissue and accounting for less than 5% of the total T cells in the peripheral blood. By bridging innate and adaptive immunity, γδ T cells play important roles in the anti-infection, antitumor, and autoimmune responses. Previous research on γδ T cells was primarily concentrated on infectious diseases and tumors, whereas their functions in autoimmune diseases attracted much attention. In this paper, we summarized the various functions of γδ T cells in two prototypical autoimmune connective tissue diseases, that is, SLE and RA, elaborating on their antigen-presenting capacity, secretion of proinflammatory cytokines, immunomodulatory effects, and auxiliary function for B cells, which contribute to overproduction of proinflammatory cytokines and pathogenic autoantibodies, ultimately leading to the onset of these autoimmune diseases. Elucidation of the roles of γδ T cells in autoimmune diseases is not only conducive to in-depth understanding of the pathogenesis of these diseases, but also beneficial in providing theoretical support for the development of γδ T-cell-targeted therapy.http://dx.doi.org/10.1155/2013/985753 |
| spellingShingle | Dinglei Su Minning Shen Xia Li Lingyun Sun Roles of T Cells in the Pathogenesis of Autoimmune Diseases Clinical and Developmental Immunology |
| title | Roles of T Cells in the Pathogenesis of Autoimmune Diseases |
| title_full | Roles of T Cells in the Pathogenesis of Autoimmune Diseases |
| title_fullStr | Roles of T Cells in the Pathogenesis of Autoimmune Diseases |
| title_full_unstemmed | Roles of T Cells in the Pathogenesis of Autoimmune Diseases |
| title_short | Roles of T Cells in the Pathogenesis of Autoimmune Diseases |
| title_sort | roles of t cells in the pathogenesis of autoimmune diseases |
| url | http://dx.doi.org/10.1155/2013/985753 |
| work_keys_str_mv | AT dingleisu rolesoftcellsinthepathogenesisofautoimmunediseases AT minningshen rolesoftcellsinthepathogenesisofautoimmunediseases AT xiali rolesoftcellsinthepathogenesisofautoimmunediseases AT lingyunsun rolesoftcellsinthepathogenesisofautoimmunediseases |