Spectrophotometric and computational characterization of charge transfer complex of selumetinib with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and its utilization in developing an innovative green and high throughput microwell assay for analysis of bulk form and pharmaceutical formulation

Spectrophotometric and computational characterization of charge transfer complex of selumetinib with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and its utilization in developing an innovative green and high throughput microwell assay for analysis of bulk form and pharmaceutical formulation

Abstract For paediatric patients suffering from neurofibromatosis, Selumetinib (SEL) is the only approved drug. Here an original ecofriendly and high pace method is introduced using 96- microwell spectrophotometric assay (MW-SPA) to measure SEL content in bulk and commercial pharmaceutical formulati...

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Bibliographic Details
Main Authors: Sarah Alrubia, Wafa A. AlShehri, Awwad A. Radwan, Nourah Z. Alzoman, Ibrahim A. Darwish
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Chemistry
Subjects:
Selumetinib
Charge transfer complex
DDQ
Spectrophotometry
Computational studies, Microwell analysis
Online Access:https://doi.org/10.1186/s13065-024-01353-6
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