Emerging roles of epigenetic regulators during lung development
Abstract Epigenetic pathways, including DNA methylation, non-coding RNAs, histone modification, and chromatin remodeling, control spatiotemporal gene expression and tightly coordinate the activities during embryogenesis. Emerging evidence indicates that epigenetic regulators are critically required...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-07-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07823-6 |
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| _version_ | 1849235790381449216 |
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| author | Guohua Meng Wenli Yin Yue Hong Salvatore Oliviero |
| author_facet | Guohua Meng Wenli Yin Yue Hong Salvatore Oliviero |
| author_sort | Guohua Meng |
| collection | DOAJ |
| description | Abstract Epigenetic pathways, including DNA methylation, non-coding RNAs, histone modification, and chromatin remodeling, control spatiotemporal gene expression and tightly coordinate the activities during embryogenesis. Emerging evidence indicates that epigenetic regulators are critically required for the maintenance of normal lung development and that the epigenetic marks are altered in lung cells during disease progression. In this review, we focus on the recent studies that have yielded insights into how the levels and patterns of epigenetic regulators are changed, and how these regulators contribute to the regulation of various stages during lung development. A deeper understanding of these epigenetic mechanisms could offer novel therapeutic targets for preventing fetal lung diseases. |
| format | Article |
| id | doaj-art-6bfc1698455e44fbb9d671e50247cbcb |
| institution | Kabale University |
| issn | 2041-4889 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj-art-6bfc1698455e44fbb9d671e50247cbcb2025-08-20T04:02:41ZengNature Publishing GroupCell Death and Disease2041-48892025-07-0116111110.1038/s41419-025-07823-6Emerging roles of epigenetic regulators during lung developmentGuohua Meng0Wenli Yin1Yue Hong2Salvatore Oliviero3School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan UniversitySchool of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan UniversitySchool of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan UniversityDepartment of Life Sciences and Systems Biology, University of TurinAbstract Epigenetic pathways, including DNA methylation, non-coding RNAs, histone modification, and chromatin remodeling, control spatiotemporal gene expression and tightly coordinate the activities during embryogenesis. Emerging evidence indicates that epigenetic regulators are critically required for the maintenance of normal lung development and that the epigenetic marks are altered in lung cells during disease progression. In this review, we focus on the recent studies that have yielded insights into how the levels and patterns of epigenetic regulators are changed, and how these regulators contribute to the regulation of various stages during lung development. A deeper understanding of these epigenetic mechanisms could offer novel therapeutic targets for preventing fetal lung diseases.https://doi.org/10.1038/s41419-025-07823-6 |
| spellingShingle | Guohua Meng Wenli Yin Yue Hong Salvatore Oliviero Emerging roles of epigenetic regulators during lung development Cell Death and Disease |
| title | Emerging roles of epigenetic regulators during lung development |
| title_full | Emerging roles of epigenetic regulators during lung development |
| title_fullStr | Emerging roles of epigenetic regulators during lung development |
| title_full_unstemmed | Emerging roles of epigenetic regulators during lung development |
| title_short | Emerging roles of epigenetic regulators during lung development |
| title_sort | emerging roles of epigenetic regulators during lung development |
| url | https://doi.org/10.1038/s41419-025-07823-6 |
| work_keys_str_mv | AT guohuameng emergingrolesofepigeneticregulatorsduringlungdevelopment AT wenliyin emergingrolesofepigeneticregulatorsduringlungdevelopment AT yuehong emergingrolesofepigeneticregulatorsduringlungdevelopment AT salvatoreoliviero emergingrolesofepigeneticregulatorsduringlungdevelopment |