Transcriptional Modulation of Heat-Shock Protein Gene Expression
Heat-shock proteins (Hsps) are molecular chaperones that are ubiquitously expressed but are also induced in cells exposed to stressful stimuli. Hsps have been implicated in the induction and propagation of several diseases. This paper focuses on regulatory factors that control the transcription of t...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2011/238601 |
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| author | Anastasis Stephanou David S. Latchman |
| author_facet | Anastasis Stephanou David S. Latchman |
| author_sort | Anastasis Stephanou |
| collection | DOAJ |
| description | Heat-shock proteins (Hsps) are molecular chaperones that are ubiquitously expressed but are also induced in cells exposed to stressful stimuli. Hsps have been implicated in the induction and propagation of several diseases. This paper focuses on regulatory factors that control the transcription of the genes encoding Hsps. We also highlight how distinct transcription factors are able to interact and modulate Hsps in different pathological states. Thus, a better understanding of the complex signaling pathways regulating Hsp expression may lead to novel therapeutic targets. |
| format | Article |
| id | doaj-art-6bf84143d4f146bca744f9afe63b326f |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-6bf84143d4f146bca744f9afe63b326f2025-08-20T03:33:46ZengWileyBiochemistry Research International2090-22472090-22552011-01-01201110.1155/2011/238601238601Transcriptional Modulation of Heat-Shock Protein Gene ExpressionAnastasis Stephanou0David S. Latchman1Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UKMedical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UKHeat-shock proteins (Hsps) are molecular chaperones that are ubiquitously expressed but are also induced in cells exposed to stressful stimuli. Hsps have been implicated in the induction and propagation of several diseases. This paper focuses on regulatory factors that control the transcription of the genes encoding Hsps. We also highlight how distinct transcription factors are able to interact and modulate Hsps in different pathological states. Thus, a better understanding of the complex signaling pathways regulating Hsp expression may lead to novel therapeutic targets.http://dx.doi.org/10.1155/2011/238601 |
| spellingShingle | Anastasis Stephanou David S. Latchman Transcriptional Modulation of Heat-Shock Protein Gene Expression Biochemistry Research International |
| title | Transcriptional Modulation of Heat-Shock Protein Gene Expression |
| title_full | Transcriptional Modulation of Heat-Shock Protein Gene Expression |
| title_fullStr | Transcriptional Modulation of Heat-Shock Protein Gene Expression |
| title_full_unstemmed | Transcriptional Modulation of Heat-Shock Protein Gene Expression |
| title_short | Transcriptional Modulation of Heat-Shock Protein Gene Expression |
| title_sort | transcriptional modulation of heat shock protein gene expression |
| url | http://dx.doi.org/10.1155/2011/238601 |
| work_keys_str_mv | AT anastasisstephanou transcriptionalmodulationofheatshockproteingeneexpression AT davidslatchman transcriptionalmodulationofheatshockproteingeneexpression |