Resistance and resilience to tau pathology in Alzheimer's disease: Effects of age, sex, and APOE alleles

Resistance and resilience to tau pathology in Alzheimer's disease: Effects of age, sex, and APOE alleles

Abstract INTRODUCTION Neurofibrillary tangles (NFTs), a hallmark of tau pathology in Alzheimer's disease (AD), accumulate in the aging brain. However, some individuals remain cognitively intact despite high Braak (III–VI) stages, which characterize NFTs’ accumulation. METHODS We studied resista...

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Bibliographic Details
Main Authors: Yury Loika, Stephanie Webster, Elena Loiko, Alexander M. Kulminski
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
aging
tau pathology
Alzheimer's disease
APOE allele
Braak stages
cognitive health
Online Access:https://doi.org/10.1002/dad2.70016
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