Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats
This study investigated the effects of polysaccharides from Enteromorpha prolifera (PEP) on glucose metabolism in a rat model of diabetes mellitus (DM). PEP (0, 150, 300, and 600 mg/kg) was administered intragastrically to rats for four weeks. After treatment, fasting blood glucose (FBG) and insulin...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/675201 |
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| author | Wenting Lin Wenxiang Wang Dongdong Liao Damiao Chen Pingping Zhu Guoxi Cai Aoyagi Kiyoshi |
| author_facet | Wenting Lin Wenxiang Wang Dongdong Liao Damiao Chen Pingping Zhu Guoxi Cai Aoyagi Kiyoshi |
| author_sort | Wenting Lin |
| collection | DOAJ |
| description | This study investigated the effects of polysaccharides from Enteromorpha prolifera (PEP) on glucose metabolism in a rat model of diabetes mellitus (DM). PEP (0, 150, 300, and 600 mg/kg) was administered intragastrically to rats for four weeks. After treatment, fasting blood glucose (FBG) and insulin (INS) levels were measured, and the insulin sensitivity index (ISI) was calculated. The morphopathological changes in the pancreas were observed. Serum samples were collected to measure the oxidant-antioxidant status. The mRNA expression levels of glucokinase (GCK) and insulin receptor (InsR) in liver tissue and glucose transporter type 4 (GLUT-4) and adiponectin (APN) in adipose tissue were determined. Compared with the model group, the FBG and INS levels were lower, the ISI was higher, and the number of islet β-cells was significantly increased in all the PEP groups. In the medium- and high-dose PEP groups, MDA levels decreased, and the enzymatic activities of SOD and GSH-Px increased. The mRNA expression of InsR and GCK increased in all the PEP groups; APN mRNA expression increased in the high-dose PEP group, and GLUT-4 mRNA expression increased in adipose tissue. These findings suggest that PEP is a potential therapeutic agent that can be utilized to treat DM. |
| format | Article |
| id | doaj-art-6bf5bbc7d02a4c0e9ff5ab337341642c |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-6bf5bbc7d02a4c0e9ff5ab337341642c2025-08-20T02:06:11ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/675201675201Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic RatsWenting Lin0Wenxiang Wang1Dongdong Liao2Damiao Chen3Pingping Zhu4Guoxi Cai5Aoyagi Kiyoshi6Department of Nutrition and Health Care, School of Public Health, Fujian Medical University, Fuzhou, Fujian 350108, ChinaDepartment of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou, Fujian 350108, ChinaDepartment of Nutrition and Health Care, School of Public Health, Fujian Medical University, Fuzhou, Fujian 350108, ChinaDepartment of Nutrition and Health Care, School of Public Health, Fujian Medical University, Fuzhou, Fujian 350108, ChinaDepartment of Nutrition and Health Care, School of Public Health, Fujian Medical University, Fuzhou, Fujian 350108, ChinaInstitute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, JapanDepartment of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, JapanThis study investigated the effects of polysaccharides from Enteromorpha prolifera (PEP) on glucose metabolism in a rat model of diabetes mellitus (DM). PEP (0, 150, 300, and 600 mg/kg) was administered intragastrically to rats for four weeks. After treatment, fasting blood glucose (FBG) and insulin (INS) levels were measured, and the insulin sensitivity index (ISI) was calculated. The morphopathological changes in the pancreas were observed. Serum samples were collected to measure the oxidant-antioxidant status. The mRNA expression levels of glucokinase (GCK) and insulin receptor (InsR) in liver tissue and glucose transporter type 4 (GLUT-4) and adiponectin (APN) in adipose tissue were determined. Compared with the model group, the FBG and INS levels were lower, the ISI was higher, and the number of islet β-cells was significantly increased in all the PEP groups. In the medium- and high-dose PEP groups, MDA levels decreased, and the enzymatic activities of SOD and GSH-Px increased. The mRNA expression of InsR and GCK increased in all the PEP groups; APN mRNA expression increased in the high-dose PEP group, and GLUT-4 mRNA expression increased in adipose tissue. These findings suggest that PEP is a potential therapeutic agent that can be utilized to treat DM.http://dx.doi.org/10.1155/2015/675201 |
| spellingShingle | Wenting Lin Wenxiang Wang Dongdong Liao Damiao Chen Pingping Zhu Guoxi Cai Aoyagi Kiyoshi Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats Journal of Diabetes Research |
| title | Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats |
| title_full | Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats |
| title_fullStr | Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats |
| title_full_unstemmed | Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats |
| title_short | Polysaccharides from Enteromorpha prolifera Improve Glucose Metabolism in Diabetic Rats |
| title_sort | polysaccharides from enteromorpha prolifera improve glucose metabolism in diabetic rats |
| url | http://dx.doi.org/10.1155/2015/675201 |
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