Phloretin-nanospanlastics for targeting the Akt/PI3K signaling pathways in dimethylhydrazine-induced colon cancer in mice

Phloretin-nanospanlastics for targeting the Akt/PI3K signaling pathways in dimethylhydrazine-induced colon cancer in mice

Objectives: Colorectal cancer is the third most common cancer worldwide, accounting for approximately 10 % of all cancer cases. It is also the second leading cause of cancer-related deaths globally. Phloretin is a natural compound found in apples and other fruits. It has been studied for its potenti...

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Main Authors: Ebtsam A. Abdel-Wahab, Zahraa Haleem Al-Qaim, Ahmed T.H. Faris Al-Karkhi, Aysam M. Fayed, Ahmed M. Eldmrdash, Mohammed Abdalla Hussein, Amal Abdel-Aziz, Azza M. Metwaly, Heba.G. Abdelzaher, M.A. Abdelzaher, Diana A. ALsherif
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:International Journal of Pharmaceutics: X
Subjects:
Colon Cancer
Phloretin-Nanospanlastics
Akt/PI3K
Dimethylhydrazine
Inflammatory Mediators
Antioxidants
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156724000835
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