Ultra-sensitive heterojunction double gate BioTFET device for SARS-CoV-2 biomolecules detection
Abstract The persisting SARS-CoV-2 genetic mutation could unintentionally increase human transmission, mortality, and aggravation. Since no specific pharmaceutical therapies or vaccinations exist, rapid detection and successful treatment are essential for managing the COVID-19 pandemic. BioTFETs exh...
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-99817-9 |
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| author | P. Vimala A. Sharon Geege N. Mohankumar T. S. Arun Samuel T. Ananth Kumar P. Suveetha Dhanaselvam I. Vivek Anand |
| author_facet | P. Vimala A. Sharon Geege N. Mohankumar T. S. Arun Samuel T. Ananth Kumar P. Suveetha Dhanaselvam I. Vivek Anand |
| author_sort | P. Vimala |
| collection | DOAJ |
| description | Abstract The persisting SARS-CoV-2 genetic mutation could unintentionally increase human transmission, mortality, and aggravation. Since no specific pharmaceutical therapies or vaccinations exist, rapid detection and successful treatment are essential for managing the COVID-19 pandemic. BioTFETs exhibit superior sensitivity and faster response times than bioFETs, which are more vulnerable to substantial subthreshold swing and short-channel effects. This article presents the Dielectrically Modulated-Double Gate-Heterojunction-Tunnel FET-based biosensor (DG-bioHTFET) specifically engineered to identify and detect the nucleocapsid protein and RNA biomolecules with specific permittivity (k) of SARS-CoV-2 biomolecules embedded in the nanogaps. At Vgs = 1.5 V, the proposed device achieves a drain current (Ids) of 2.32 × 10− 5 A/µm. At k = 5 and k = 3.64, the ION/IOFF ratios are 3.550 × 105 and 3.403 × 105, respectively. The data suggest that the device exhibits increased sensitivity to biomolecules possessing elevated dielectric constants. It is feasible to design ultra-sensitive TFET biosensors as a bio-recognition unit, which offers the benefits of rapid label-free detection and high sensitivity. The device exhibits superior performance in terms of high drain current with enhanced sensitivity for precise biosensing applications. |
| format | Article |
| id | doaj-art-6be947527ec14232a7a95bae75225cbf |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6be947527ec14232a7a95bae75225cbf2025-08-20T03:52:19ZengNature PortfolioScientific Reports2045-23222025-04-0115111310.1038/s41598-025-99817-9Ultra-sensitive heterojunction double gate BioTFET device for SARS-CoV-2 biomolecules detectionP. Vimala0A. Sharon Geege1N. Mohankumar2T. S. Arun Samuel3T. Ananth Kumar4P. Suveetha Dhanaselvam5I. Vivek Anand6Electronics and Communication Engineering, Dayananda Sagar College of EngineeringElectronics and Communication Engineering, National Engineering CollegeSymbiosis Institute of Technology, Nagpur Campus, Symbiosis International (Deemed University)Electronics and Communication Engineering, National Engineering CollegeComputer Science and Engineering, IFET College of Engineering Electronics and Communication Engineering, Velammal College of Engineering & TechnologyElectronics and Communication Engineering, National Engineering CollegeAbstract The persisting SARS-CoV-2 genetic mutation could unintentionally increase human transmission, mortality, and aggravation. Since no specific pharmaceutical therapies or vaccinations exist, rapid detection and successful treatment are essential for managing the COVID-19 pandemic. BioTFETs exhibit superior sensitivity and faster response times than bioFETs, which are more vulnerable to substantial subthreshold swing and short-channel effects. This article presents the Dielectrically Modulated-Double Gate-Heterojunction-Tunnel FET-based biosensor (DG-bioHTFET) specifically engineered to identify and detect the nucleocapsid protein and RNA biomolecules with specific permittivity (k) of SARS-CoV-2 biomolecules embedded in the nanogaps. At Vgs = 1.5 V, the proposed device achieves a drain current (Ids) of 2.32 × 10− 5 A/µm. At k = 5 and k = 3.64, the ION/IOFF ratios are 3.550 × 105 and 3.403 × 105, respectively. The data suggest that the device exhibits increased sensitivity to biomolecules possessing elevated dielectric constants. It is feasible to design ultra-sensitive TFET biosensors as a bio-recognition unit, which offers the benefits of rapid label-free detection and high sensitivity. The device exhibits superior performance in terms of high drain current with enhanced sensitivity for precise biosensing applications.https://doi.org/10.1038/s41598-025-99817-9Tunnel field effect transistorSARS-CoV-2SensitivityDouble gateHeterojunction |
| spellingShingle | P. Vimala A. Sharon Geege N. Mohankumar T. S. Arun Samuel T. Ananth Kumar P. Suveetha Dhanaselvam I. Vivek Anand Ultra-sensitive heterojunction double gate BioTFET device for SARS-CoV-2 biomolecules detection Scientific Reports Tunnel field effect transistor SARS-CoV-2 Sensitivity Double gate Heterojunction |
| title | Ultra-sensitive heterojunction double gate BioTFET device for SARS-CoV-2 biomolecules detection |
| title_full | Ultra-sensitive heterojunction double gate BioTFET device for SARS-CoV-2 biomolecules detection |
| title_fullStr | Ultra-sensitive heterojunction double gate BioTFET device for SARS-CoV-2 biomolecules detection |
| title_full_unstemmed | Ultra-sensitive heterojunction double gate BioTFET device for SARS-CoV-2 biomolecules detection |
| title_short | Ultra-sensitive heterojunction double gate BioTFET device for SARS-CoV-2 biomolecules detection |
| title_sort | ultra sensitive heterojunction double gate biotfet device for sars cov 2 biomolecules detection |
| topic | Tunnel field effect transistor SARS-CoV-2 Sensitivity Double gate Heterojunction |
| url | https://doi.org/10.1038/s41598-025-99817-9 |
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