Frontier applications of retinal nanomedicine: progress, challenges and perspectives
Abstract The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration and permanent vision loss. Effective therapeutic strategies are restricted to the treatment or reversal of these conditions. In...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03095-6 |
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| author | Zhimin Tang Fuxiang Ye Ni Ni Xianqun Fan Linna Lu Ping Gu |
| author_facet | Zhimin Tang Fuxiang Ye Ni Ni Xianqun Fan Linna Lu Ping Gu |
| author_sort | Zhimin Tang |
| collection | DOAJ |
| description | Abstract The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration and permanent vision loss. Effective therapeutic strategies are restricted to the treatment or reversal of these conditions. In recent years, nanoscience and nanotechnology have revolutionized targeted management of retinal diseases. Pharmaceuticals, theranostics, regenerative medicine, gene therapy, and retinal prostheses are indispensable for retinal interventions and have been significantly advanced by nanomedical innovations. Hence, this review presents novel insights into the use of versatile nanomaterial-based nanocomposites for frontier retinal applications, including non-invasive drug delivery, theranostic contrast agents, therapeutic nanoagents, gene therapy, stem cell-based therapy, retinal optogenetics and retinal prostheses, which have mainly been reported within the last 5 years. Furthermore, recent progress, potential challenges, and future perspectives in this field are highlighted and discussed in detail, which may shed light on future clinical translations and ultimately, benefit patients with retinal disorders. Graphical Abstract |
| format | Article |
| id | doaj-art-6be646fa2905414c9ea6908d47bdeb5f |
| institution | DOAJ |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-6be646fa2905414c9ea6908d47bdeb5f2025-08-20T02:54:37ZengBMCJournal of Nanobiotechnology1477-31552025-02-0123115010.1186/s12951-025-03095-6Frontier applications of retinal nanomedicine: progress, challenges and perspectivesZhimin Tang0Fuxiang Ye1Ni Ni2Xianqun Fan3Linna Lu4Ping Gu5Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineAbstract The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration and permanent vision loss. Effective therapeutic strategies are restricted to the treatment or reversal of these conditions. In recent years, nanoscience and nanotechnology have revolutionized targeted management of retinal diseases. Pharmaceuticals, theranostics, regenerative medicine, gene therapy, and retinal prostheses are indispensable for retinal interventions and have been significantly advanced by nanomedical innovations. Hence, this review presents novel insights into the use of versatile nanomaterial-based nanocomposites for frontier retinal applications, including non-invasive drug delivery, theranostic contrast agents, therapeutic nanoagents, gene therapy, stem cell-based therapy, retinal optogenetics and retinal prostheses, which have mainly been reported within the last 5 years. Furthermore, recent progress, potential challenges, and future perspectives in this field are highlighted and discussed in detail, which may shed light on future clinical translations and ultimately, benefit patients with retinal disorders. Graphical Abstracthttps://doi.org/10.1186/s12951-025-03095-6Retinal diseasesNanomedicineEye dropTherapeutic nanoagentsTheranosticGene therapy |
| spellingShingle | Zhimin Tang Fuxiang Ye Ni Ni Xianqun Fan Linna Lu Ping Gu Frontier applications of retinal nanomedicine: progress, challenges and perspectives Journal of Nanobiotechnology Retinal diseases Nanomedicine Eye drop Therapeutic nanoagents Theranostic Gene therapy |
| title | Frontier applications of retinal nanomedicine: progress, challenges and perspectives |
| title_full | Frontier applications of retinal nanomedicine: progress, challenges and perspectives |
| title_fullStr | Frontier applications of retinal nanomedicine: progress, challenges and perspectives |
| title_full_unstemmed | Frontier applications of retinal nanomedicine: progress, challenges and perspectives |
| title_short | Frontier applications of retinal nanomedicine: progress, challenges and perspectives |
| title_sort | frontier applications of retinal nanomedicine progress challenges and perspectives |
| topic | Retinal diseases Nanomedicine Eye drop Therapeutic nanoagents Theranostic Gene therapy |
| url | https://doi.org/10.1186/s12951-025-03095-6 |
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