Effect of Antibacterial ε-Polylysine on Collagen Self-assembly
This study investigated the impact of antimicrobial peptide polylysine (ε-PL) on collagen (Col) self-assembly under physiological conditions. The results indicated that the cationic ε-PL had a decelerating effect on the collagen self-assembly process, leading to a looser network structure and a decr...
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| Format: | Article |
| Language: | zho |
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Leather Science and Engineering Editorial Office
2024-11-01
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| Series: | Pige Kexue Yu Gongcheng |
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| Online Access: | http://www.scupgkg.cn/article/doi/10.12472/j.issn.1004-7964.202400115 |
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| author | Xiaoxia ZHANG Guoying LI |
| author_facet | Xiaoxia ZHANG Guoying LI |
| author_sort | Xiaoxia ZHANG |
| collection | DOAJ |
| description | This study investigated the impact of antimicrobial peptide polylysine (ε-PL) on collagen (Col) self-assembly under physiological conditions. The results indicated that the cationic ε-PL had a decelerating effect on the collagen self-assembly process, leading to a looser network structure and a decrease in the fibril diameter of collagen assemblies. When the Col/ε-PL ratio was below 1∶0.5, well-defined collagen fibrils with D-periodicity were observed, and the thermal stability of the Col/ε-PL assemblies was similar to that of pure collagen assemblies. Moreover, the introduction of ε-PL also enhanced the antimicrobial activity of the Col/ε-PL assemblies. Therefore, incorporating an optimal amount of ε-PL into collagen self-assembly represents a promising approach for developing antimicrobial biomimetic collagen fibrils. |
| format | Article |
| id | doaj-art-6be5371fe6774d4aa2d1db5402c91334 |
| institution | Kabale University |
| issn | 1004-7964 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Leather Science and Engineering Editorial Office |
| record_format | Article |
| series | Pige Kexue Yu Gongcheng |
| spelling | doaj-art-6be5371fe6774d4aa2d1db5402c913342025-08-20T03:24:14ZzhoLeather Science and Engineering Editorial OfficePige Kexue Yu Gongcheng1004-79642024-11-0135181410.12472/j.issn.1004-7964.2024001152024-00115Effect of Antibacterial ε-Polylysine on Collagen Self-assemblyXiaoxia ZHANG0Guoying LI1Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, ChinaKey Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, ChinaThis study investigated the impact of antimicrobial peptide polylysine (ε-PL) on collagen (Col) self-assembly under physiological conditions. The results indicated that the cationic ε-PL had a decelerating effect on the collagen self-assembly process, leading to a looser network structure and a decrease in the fibril diameter of collagen assemblies. When the Col/ε-PL ratio was below 1∶0.5, well-defined collagen fibrils with D-periodicity were observed, and the thermal stability of the Col/ε-PL assemblies was similar to that of pure collagen assemblies. Moreover, the introduction of ε-PL also enhanced the antimicrobial activity of the Col/ε-PL assemblies. Therefore, incorporating an optimal amount of ε-PL into collagen self-assembly represents a promising approach for developing antimicrobial biomimetic collagen fibrils.http://www.scupgkg.cn/article/doi/10.12472/j.issn.1004-7964.202400115collagenε-polylysineself-assemblycollagen fibrilantibacterial |
| spellingShingle | Xiaoxia ZHANG Guoying LI Effect of Antibacterial ε-Polylysine on Collagen Self-assembly Pige Kexue Yu Gongcheng collagen ε-polylysine self-assembly collagen fibril antibacterial |
| title | Effect of Antibacterial ε-Polylysine on Collagen Self-assembly |
| title_full | Effect of Antibacterial ε-Polylysine on Collagen Self-assembly |
| title_fullStr | Effect of Antibacterial ε-Polylysine on Collagen Self-assembly |
| title_full_unstemmed | Effect of Antibacterial ε-Polylysine on Collagen Self-assembly |
| title_short | Effect of Antibacterial ε-Polylysine on Collagen Self-assembly |
| title_sort | effect of antibacterial ε polylysine on collagen self assembly |
| topic | collagen ε-polylysine self-assembly collagen fibril antibacterial |
| url | http://www.scupgkg.cn/article/doi/10.12472/j.issn.1004-7964.202400115 |
| work_keys_str_mv | AT xiaoxiazhang effectofantibacterialepolylysineoncollagenselfassembly AT guoyingli effectofantibacterialepolylysineoncollagenselfassembly |