The Association between a 24-Hour Blood Pressure Pattern and Circadian Change in Plasma Aldosterone Concentration for Patients with Aldosterone-Producing Adenoma
The absence of nocturnal blood pressure (BP) decline is associated with hypertensive complications. Data regarding circadian BP patterns in patients with aldosterone-producing adenoma (APA) are limited and equivocal. We evaluated the circadian BP profile in patients with APA and its relationship wit...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/4828402 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850222902275735552 |
|---|---|
| author | Hai Li Jianbin Liu Juan Liu Liehua Liu Minmin Huang Guohong Wei Wanping Deng Zhimin Huang Xiaopei Cao Haipeng Xiao Yanbing Li |
| author_facet | Hai Li Jianbin Liu Juan Liu Liehua Liu Minmin Huang Guohong Wei Wanping Deng Zhimin Huang Xiaopei Cao Haipeng Xiao Yanbing Li |
| author_sort | Hai Li |
| collection | DOAJ |
| description | The absence of nocturnal blood pressure (BP) decline is associated with hypertensive complications. Data regarding circadian BP patterns in patients with aldosterone-producing adenoma (APA) are limited and equivocal. We evaluated the circadian BP profile in patients with APA and its relationship with the circadian aldosterone rhythm. BP in patients with APA and in those with essential hypertension (EH) were assessed through in-hospital 24-h ambulatory blood pressure monitoring. Over a 24-h in-hospital period, plasma aldosterone levels taken at midnight, 0400, 0800, 1200, 1600, and 2000 h were measured. To evaluate a correlation between BP and hormone rhythm, we included 27 patients with APA (APA group) and 27 patients with EH (EH group). Both groups had similar age, sex ratio, body mass index, duration of hypertension, family history of hypertension, and lipid profiles. The day-night BP differences in both patient groups were similar, whether expressed as absolute values or percentages. The proportions of patients with dipping BP profiles were also comparable (APA group, 5 of 27; EH group, 7 of 27; χ2 = 0.429; P = 0.513). At each time point, APA group plasma aldosterone concentrations (PACs) were higher than those of the EH group. A circadian change in relation to PAC was observed in both groups. A correlation between PAC and BP was statistically nonsignificant in most study patients in either group. Our data indicated that the circadian BP pattern was not associated with a change in PAC levels in patients with APA. |
| format | Article |
| id | doaj-art-6bdac7efc75f4f0bad072f7bbb95b74a |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6bdac7efc75f4f0bad072f7bbb95b74a2025-08-20T02:06:11ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/48284024828402The Association between a 24-Hour Blood Pressure Pattern and Circadian Change in Plasma Aldosterone Concentration for Patients with Aldosterone-Producing AdenomaHai Li0Jianbin Liu1Juan Liu2Liehua Liu3Minmin Huang4Guohong Wei5Wanping Deng6Zhimin Huang7Xiaopei Cao8Haipeng Xiao9Yanbing Li10Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Medicine, Eastern Health, Box Hill, VIC 3128, AustraliaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaThe absence of nocturnal blood pressure (BP) decline is associated with hypertensive complications. Data regarding circadian BP patterns in patients with aldosterone-producing adenoma (APA) are limited and equivocal. We evaluated the circadian BP profile in patients with APA and its relationship with the circadian aldosterone rhythm. BP in patients with APA and in those with essential hypertension (EH) were assessed through in-hospital 24-h ambulatory blood pressure monitoring. Over a 24-h in-hospital period, plasma aldosterone levels taken at midnight, 0400, 0800, 1200, 1600, and 2000 h were measured. To evaluate a correlation between BP and hormone rhythm, we included 27 patients with APA (APA group) and 27 patients with EH (EH group). Both groups had similar age, sex ratio, body mass index, duration of hypertension, family history of hypertension, and lipid profiles. The day-night BP differences in both patient groups were similar, whether expressed as absolute values or percentages. The proportions of patients with dipping BP profiles were also comparable (APA group, 5 of 27; EH group, 7 of 27; χ2 = 0.429; P = 0.513). At each time point, APA group plasma aldosterone concentrations (PACs) were higher than those of the EH group. A circadian change in relation to PAC was observed in both groups. A correlation between PAC and BP was statistically nonsignificant in most study patients in either group. Our data indicated that the circadian BP pattern was not associated with a change in PAC levels in patients with APA.http://dx.doi.org/10.1155/2019/4828402 |
| spellingShingle | Hai Li Jianbin Liu Juan Liu Liehua Liu Minmin Huang Guohong Wei Wanping Deng Zhimin Huang Xiaopei Cao Haipeng Xiao Yanbing Li The Association between a 24-Hour Blood Pressure Pattern and Circadian Change in Plasma Aldosterone Concentration for Patients with Aldosterone-Producing Adenoma International Journal of Endocrinology |
| title | The Association between a 24-Hour Blood Pressure Pattern and Circadian Change in Plasma Aldosterone Concentration for Patients with Aldosterone-Producing Adenoma |
| title_full | The Association between a 24-Hour Blood Pressure Pattern and Circadian Change in Plasma Aldosterone Concentration for Patients with Aldosterone-Producing Adenoma |
| title_fullStr | The Association between a 24-Hour Blood Pressure Pattern and Circadian Change in Plasma Aldosterone Concentration for Patients with Aldosterone-Producing Adenoma |
| title_full_unstemmed | The Association between a 24-Hour Blood Pressure Pattern and Circadian Change in Plasma Aldosterone Concentration for Patients with Aldosterone-Producing Adenoma |
| title_short | The Association between a 24-Hour Blood Pressure Pattern and Circadian Change in Plasma Aldosterone Concentration for Patients with Aldosterone-Producing Adenoma |
| title_sort | association between a 24 hour blood pressure pattern and circadian change in plasma aldosterone concentration for patients with aldosterone producing adenoma |
| url | http://dx.doi.org/10.1155/2019/4828402 |
| work_keys_str_mv | AT haili theassociationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT jianbinliu theassociationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT juanliu theassociationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT liehualiu theassociationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT minminhuang theassociationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT guohongwei theassociationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT wanpingdeng theassociationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT zhiminhuang theassociationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT xiaopeicao theassociationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT haipengxiao theassociationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT yanbingli theassociationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT haili associationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT jianbinliu associationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT juanliu associationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT liehualiu associationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT minminhuang associationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT guohongwei associationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT wanpingdeng associationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT zhiminhuang associationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT xiaopeicao associationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT haipengxiao associationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma AT yanbingli associationbetweena24hourbloodpressurepatternandcircadianchangeinplasmaaldosteroneconcentrationforpatientswithaldosteroneproducingadenoma |