A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer

We reviewed more than 3,000 pathology reports on prostate cancer-related surgical specimens and analyzed racial disparities in histological and clinical features at the time of initial biopsy, diagnosis of prostate cancer, and prostatectomy, as well as in characteristics of tumor evolution between A...

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Main Authors: Steven A. Bigler, Charles R. Pound, Xinchun Zhou
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Prostate Cancer
Online Access:http://dx.doi.org/10.1155/2011/239460
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author Steven A. Bigler
Charles R. Pound
Xinchun Zhou
author_facet Steven A. Bigler
Charles R. Pound
Xinchun Zhou
author_sort Steven A. Bigler
collection DOAJ
description We reviewed more than 3,000 pathology reports on prostate cancer-related surgical specimens and analyzed racial disparities in histological and clinical features at the time of initial biopsy, diagnosis of prostate cancer, and prostatectomy, as well as in characteristics of tumor evolution between African American and Caucasian patients. As compared to Caucasians, African American patients had younger age, higher cancer detection rate, higher Gleason score of prostate cancer, and more bilateral involvement of the prostate. African Americans also had larger prostates, greater volume of tumor, and more positive margins. The diagnosis of HGPIN or ASAP in prostate biopsies and African American race conferred an increased risk of diagnosis of prostate cancer. The interval between prior noncancerous biopsy and the subsequent biopsy with diagnosis of prostate cancer was shorter in men with HGPIN, with ASAP, or of African American race.
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series Prostate Cancer
spelling doaj-art-6bd7bfe8f64a4b31b1543de81ef150e82025-02-03T06:08:30ZengWileyProstate Cancer2090-31112090-312X2011-01-01201110.1155/2011/239460239460A Retrospective Study on Pathologic Features and Racial Disparities in Prostate CancerSteven A. Bigler0Charles R. Pound1Xinchun Zhou2Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Surgery, University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USAWe reviewed more than 3,000 pathology reports on prostate cancer-related surgical specimens and analyzed racial disparities in histological and clinical features at the time of initial biopsy, diagnosis of prostate cancer, and prostatectomy, as well as in characteristics of tumor evolution between African American and Caucasian patients. As compared to Caucasians, African American patients had younger age, higher cancer detection rate, higher Gleason score of prostate cancer, and more bilateral involvement of the prostate. African Americans also had larger prostates, greater volume of tumor, and more positive margins. The diagnosis of HGPIN or ASAP in prostate biopsies and African American race conferred an increased risk of diagnosis of prostate cancer. The interval between prior noncancerous biopsy and the subsequent biopsy with diagnosis of prostate cancer was shorter in men with HGPIN, with ASAP, or of African American race.http://dx.doi.org/10.1155/2011/239460
spellingShingle Steven A. Bigler
Charles R. Pound
Xinchun Zhou
A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer
Prostate Cancer
title A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer
title_full A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer
title_fullStr A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer
title_full_unstemmed A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer
title_short A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer
title_sort retrospective study on pathologic features and racial disparities in prostate cancer
url http://dx.doi.org/10.1155/2011/239460
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