A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer
We reviewed more than 3,000 pathology reports on prostate cancer-related surgical specimens and analyzed racial disparities in histological and clinical features at the time of initial biopsy, diagnosis of prostate cancer, and prostatectomy, as well as in characteristics of tumor evolution between A...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/239460 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549800089747456 |
|---|---|
| author | Steven A. Bigler Charles R. Pound Xinchun Zhou |
| author_facet | Steven A. Bigler Charles R. Pound Xinchun Zhou |
| author_sort | Steven A. Bigler |
| collection | DOAJ |
| description | We reviewed more than 3,000 pathology reports on prostate cancer-related surgical specimens and analyzed racial disparities in histological and clinical features at the time of initial biopsy, diagnosis of prostate cancer, and prostatectomy, as well as in characteristics of tumor evolution between African American and Caucasian patients. As compared to Caucasians, African American patients had younger age, higher cancer detection rate, higher Gleason score of prostate cancer, and more bilateral involvement of the prostate. African Americans also had larger prostates, greater volume of tumor, and more positive margins. The diagnosis of HGPIN or ASAP in prostate biopsies and African American race conferred an increased risk of diagnosis of prostate cancer. The interval between prior noncancerous biopsy and the subsequent biopsy with diagnosis of prostate cancer was shorter in men with HGPIN, with ASAP, or of African American race. |
| format | Article |
| id | doaj-art-6bd7bfe8f64a4b31b1543de81ef150e8 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-6bd7bfe8f64a4b31b1543de81ef150e82025-02-03T06:08:30ZengWileyProstate Cancer2090-31112090-312X2011-01-01201110.1155/2011/239460239460A Retrospective Study on Pathologic Features and Racial Disparities in Prostate CancerSteven A. Bigler0Charles R. Pound1Xinchun Zhou2Department of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Surgery, University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Pathology, University of Mississippi Medical Center, Jackson, MS 39216, USAWe reviewed more than 3,000 pathology reports on prostate cancer-related surgical specimens and analyzed racial disparities in histological and clinical features at the time of initial biopsy, diagnosis of prostate cancer, and prostatectomy, as well as in characteristics of tumor evolution between African American and Caucasian patients. As compared to Caucasians, African American patients had younger age, higher cancer detection rate, higher Gleason score of prostate cancer, and more bilateral involvement of the prostate. African Americans also had larger prostates, greater volume of tumor, and more positive margins. The diagnosis of HGPIN or ASAP in prostate biopsies and African American race conferred an increased risk of diagnosis of prostate cancer. The interval between prior noncancerous biopsy and the subsequent biopsy with diagnosis of prostate cancer was shorter in men with HGPIN, with ASAP, or of African American race.http://dx.doi.org/10.1155/2011/239460 |
| spellingShingle | Steven A. Bigler Charles R. Pound Xinchun Zhou A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer Prostate Cancer |
| title | A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer |
| title_full | A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer |
| title_fullStr | A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer |
| title_full_unstemmed | A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer |
| title_short | A Retrospective Study on Pathologic Features and Racial Disparities in Prostate Cancer |
| title_sort | retrospective study on pathologic features and racial disparities in prostate cancer |
| url | http://dx.doi.org/10.1155/2011/239460 |
| work_keys_str_mv | AT stevenabigler aretrospectivestudyonpathologicfeaturesandracialdisparitiesinprostatecancer AT charlesrpound aretrospectivestudyonpathologicfeaturesandracialdisparitiesinprostatecancer AT xinchunzhou aretrospectivestudyonpathologicfeaturesandracialdisparitiesinprostatecancer AT stevenabigler retrospectivestudyonpathologicfeaturesandracialdisparitiesinprostatecancer AT charlesrpound retrospectivestudyonpathologicfeaturesandracialdisparitiesinprostatecancer AT xinchunzhou retrospectivestudyonpathologicfeaturesandracialdisparitiesinprostatecancer |