cccDNA epigenetic regulator as target for therapeutical vaccine development against hepatitis B

cccDNA epigenetic regulator as target for therapeutical vaccine development against hepatitis B

Chronic hepatitis B virus infection (CHB) remains a global health concern, with currently available antiviral therapies demonstrating limited effectiveness in preventing hepatocellular carcinoma (HCC) development. Two primary challenges in CHB treatment include the persistence of the minichromosome,...

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Bibliographic Details
Main Authors: Patricia Gita Naully, Marselina Irasonia Tan, Agustiningsih Agustiningsih, Caecilia Sukowati, Ernawati Arifin Giri-Rachman
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Annals of Hepatology
Subjects:
covalently closed circular DNA
chronic hepatitis B
epigenetic
immune response
therapeutic vaccine
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268124003272
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