Prucalopride in treatment of functional chronic constipation
The aim of review. To carry out analysis of literature devoted to efficacy assessment of new prokinetic drug – 5-НТ4-receptor agonist prucalopride in treatment of patients with chronic functional constipation.Original points. Being an agonist of 5-НТ4- receptors, prucalopride stimulates motility of...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2012-02-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1255 |
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| _version_ | 1823860199956414464 |
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| author | A. A. Sheptulin |
| author_facet | A. A. Sheptulin |
| author_sort | A. A. Sheptulin |
| collection | DOAJ |
| description | The aim of review. To carry out analysis of literature devoted to efficacy assessment of new prokinetic drug – 5-НТ4-receptor agonist prucalopride in treatment of patients with chronic functional constipation.Original points. Being an agonist of 5-НТ4- receptors, prucalopride stimulates motility of the large intestine and promotes more frequent bowel movements. Numerous studies confirmed that on a background of prucalopride intake in a dose of 2 or 4 mg for 4-12 wks in patients with chronic constipation defecation frequency increases and quality of life improves. It is important, that the agent has no cardiotoxic effect and does not increase the length of Q–T interval.Conclusion. Prucalopride can be recommended for treatment of functional chronic constipation, first of all – in women, resistant to laxatives. |
| format | Article |
| id | doaj-art-6bd218606c854b64a04abbe318081dcc |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2012-02-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-6bd218606c854b64a04abbe318081dcc2025-02-10T16:14:31ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732012-02-01221913836Prucalopride in treatment of functional chronic constipationA. A. Sheptulin0ГБОУ ВПО ПМГМУ им. И.М. Сеченова РосздраваThe aim of review. To carry out analysis of literature devoted to efficacy assessment of new prokinetic drug – 5-НТ4-receptor agonist prucalopride in treatment of patients with chronic functional constipation.Original points. Being an agonist of 5-НТ4- receptors, prucalopride stimulates motility of the large intestine and promotes more frequent bowel movements. Numerous studies confirmed that on a background of prucalopride intake in a dose of 2 or 4 mg for 4-12 wks in patients with chronic constipation defecation frequency increases and quality of life improves. It is important, that the agent has no cardiotoxic effect and does not increase the length of Q–T interval.Conclusion. Prucalopride can be recommended for treatment of functional chronic constipation, first of all – in women, resistant to laxatives.https://www.gastro-j.ru/jour/article/view/1255chronic constipationslaxative resistanceprucalopride |
| spellingShingle | A. A. Sheptulin Prucalopride in treatment of functional chronic constipation Российский журнал гастроэнтерологии, гепатологии, колопроктологии chronic constipations laxative resistance prucalopride |
| title | Prucalopride in treatment of functional chronic constipation |
| title_full | Prucalopride in treatment of functional chronic constipation |
| title_fullStr | Prucalopride in treatment of functional chronic constipation |
| title_full_unstemmed | Prucalopride in treatment of functional chronic constipation |
| title_short | Prucalopride in treatment of functional chronic constipation |
| title_sort | prucalopride in treatment of functional chronic constipation |
| topic | chronic constipations laxative resistance prucalopride |
| url | https://www.gastro-j.ru/jour/article/view/1255 |
| work_keys_str_mv | AT aasheptulin prucaloprideintreatmentoffunctionalchronicconstipation |