Formaldehyde surrogates in multicomponent reactions
Formaldehyde emerges as a cornerstone in multicomponent reactions, mainly prized for its robust reactivity. Yet, alongside these beneficial traits, this highly reactive C1-building block raises concerns, primarily regarding its toxicity. One notable issue is the challenge of controlling the formatio...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2025-03-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.21.45 |
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| author | Cecilia I. Attorresi Javier A. Ramírez Bernhard Westermann |
| author_facet | Cecilia I. Attorresi Javier A. Ramírez Bernhard Westermann |
| author_sort | Cecilia I. Attorresi |
| collection | DOAJ |
| description | Formaldehyde emerges as a cornerstone in multicomponent reactions, mainly prized for its robust reactivity. Yet, alongside these beneficial traits, this highly reactive C1-building block raises concerns, primarily regarding its toxicity. One notable issue is the challenge of controlling the formation of undesired byproducts during its reactions. This review explores alternative C1-building blocks that serve as surrogates for formaldehyde, aiming to mitigate some of the challenges associated with its use in multicomponent reactions. By identifying these alternatives, toxicity concerns and improved reaction control can be addressed, paving the way for more efficient and sustainable synthetic methodologies. |
| format | Article |
| id | doaj-art-6bcfacd012f04fac85a5eb2a75f966a4 |
| institution | OA Journals |
| issn | 1860-5397 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj-art-6bcfacd012f04fac85a5eb2a75f966a42025-08-20T02:08:15ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972025-03-0121156459510.3762/bjoc.21.451860-5397-21-45Formaldehyde surrogates in multicomponent reactionsCecilia I. Attorresi0Javier A. Ramírez1Bernhard Westermann2CONICET - Universidad de Buenos Aires, Unidad de Microanálisis y Métodos Físicos en Química Orgánica (UMYMFOR), Ciudad Universitaria, Intendente Güiraldes 2160, Pabellón 2, 3° Piso, Ciudad Autónoma de Buenos Aires, C1428EGA, Argentina CONICET - Universidad de Buenos Aires, Unidad de Microanálisis y Métodos Físicos en Química Orgánica (UMYMFOR), Ciudad Universitaria, Intendente Güiraldes 2160, Pabellón 2, 3° Piso, Ciudad Autónoma de Buenos Aires, C1428EGA, Argentina Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle (Saale), Germany Formaldehyde emerges as a cornerstone in multicomponent reactions, mainly prized for its robust reactivity. Yet, alongside these beneficial traits, this highly reactive C1-building block raises concerns, primarily regarding its toxicity. One notable issue is the challenge of controlling the formation of undesired byproducts during its reactions. This review explores alternative C1-building blocks that serve as surrogates for formaldehyde, aiming to mitigate some of the challenges associated with its use in multicomponent reactions. By identifying these alternatives, toxicity concerns and improved reaction control can be addressed, paving the way for more efficient and sustainable synthetic methodologies.https://doi.org/10.3762/bjoc.21.45cascade reactionsformaldehyde surrogatesgreen chemistryheterocyclesmulticomponent reactions |
| spellingShingle | Cecilia I. Attorresi Javier A. Ramírez Bernhard Westermann Formaldehyde surrogates in multicomponent reactions Beilstein Journal of Organic Chemistry cascade reactions formaldehyde surrogates green chemistry heterocycles multicomponent reactions |
| title | Formaldehyde surrogates in multicomponent reactions |
| title_full | Formaldehyde surrogates in multicomponent reactions |
| title_fullStr | Formaldehyde surrogates in multicomponent reactions |
| title_full_unstemmed | Formaldehyde surrogates in multicomponent reactions |
| title_short | Formaldehyde surrogates in multicomponent reactions |
| title_sort | formaldehyde surrogates in multicomponent reactions |
| topic | cascade reactions formaldehyde surrogates green chemistry heterocycles multicomponent reactions |
| url | https://doi.org/10.3762/bjoc.21.45 |
| work_keys_str_mv | AT ceciliaiattorresi formaldehydesurrogatesinmulticomponentreactions AT javieraramirez formaldehydesurrogatesinmulticomponentreactions AT bernhardwestermann formaldehydesurrogatesinmulticomponentreactions |