Berberine hydrochloride inhibits the proliferation and metastasis of p53 mutant gallbladder Cancer cells by regulating the IL6/STAT3 pathway

Berberine hydrochloride inhibits the proliferation and metastasis of p53 mutant gallbladder Cancer cells by regulating the IL6/STAT3 pathway

Abstract Gallbladder cancer (GBC) is one of the most common biliary malignancies. Berberine hydrochloride, an compound extracted from the traditional Chinese medicinal plant Coptis chinensis, has potential therapeutic effects on various tumor cells. Therefore, we aimed to characterize the anticancer...

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Bibliographic Details
Main Authors: Huan Zhang, Guoning Li, Lanxin Ni, Rui Wang, Lijun Peng, Lanlan Zang, Chunlei Lu, Zhi Wang, Jinghua Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Berberine hydrochloride
P53 mutant
Gallbladder Cancer
IL-6/STAT3
Online Access:https://doi.org/10.1038/s41598-025-11480-2
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