The prognostic impact of maximal aortic diameter on acute type B aortic dissection progression in a Chinese population
Abstract Currently, evidence concerning the link between maximal aortic diameter and in-hospital mortality in cases of acute type B aortic dissection (ATBAD) is insufficient. Thus, this study aimed to explore the relationship between the maximal aortic diameter at the time of admission and the early...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-10-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-77649-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850204418938503168 |
|---|---|
| author | Xianming Tang Shuangfa Qiu Xin Sun Guifang Yang Lijuan Sheng |
| author_facet | Xianming Tang Shuangfa Qiu Xin Sun Guifang Yang Lijuan Sheng |
| author_sort | Xianming Tang |
| collection | DOAJ |
| description | Abstract Currently, evidence concerning the link between maximal aortic diameter and in-hospital mortality in cases of acute type B aortic dissection (ATBAD) is insufficient. Thus, this study aimed to explore the relationship between the maximal aortic diameter at the time of admission and the early prognosis of patients diagnosed with ATBAD. A total of 678 patients with ATBAD were included between January 2016 and December 2018, during which their clinical data was gathered. The independent variable analyzed was the maximal diameter of the aorta, while the dependent variable was mortality during hospitalization. Factors considered in this analysis included the patients’ age, gender, body mass index (BMI), medical history of hypertension, stroke, diabetes, atherosclerosis, smoking habits, chronic kidney insufficiency, time until presentation, systolic and diastolic blood pressures, ejection fraction, presence of aortic regurgitation, symptoms, involvement of abdominal vessels, laboratory findings, and treatment approaches. Of these patients collected, the mean age was 56.03 ± 12.22 years, and approximately 82.45% of them were male. After analysis, it was found that the maximal aortic diameter of patients with ATBAD was positively correlated with in-hospital mortality (OR = 1.06, 95% CI 1.03 to 1.10). Surprisingly, a J curve relationship was detected between maximal aortic diameter (point 31 mm) and in-hospital death for patients with ATBAD. The effect sizes and confidence intervals of the right (maximal aortic diameter > 31 mm) and left (maximal aortic diameter ≤ 31 mm) aspects of the inflection point were 1.06 (1.02–1.11) and 1.03 (0.83–1.28), respectively. In addition, the stratified analysis showed a stable relationship between maximal aortic diameter and in-hospital mortality, while there was no significant difference in the interaction between different subgroups. In patients with ATBAD, a J-curve relationship was identified between the maximal aortic diameter and in-hospital mortality. Specifically, when the maximal aortic diameter exceeds 31 mm, a positive correlation with in-hospital death was observed. |
| format | Article |
| id | doaj-art-6bcd22a833774712aad5d79c07eade34 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6bcd22a833774712aad5d79c07eade342025-08-20T02:11:17ZengNature PortfolioScientific Reports2045-23222024-10-0114111110.1038/s41598-024-77649-3The prognostic impact of maximal aortic diameter on acute type B aortic dissection progression in a Chinese populationXianming Tang0Shuangfa Qiu1Xin Sun2Guifang Yang3Lijuan Sheng4Department of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityCollege of Nursing, Changsha Medical UniversityDepartment of Emergency Medicine, The Second Xiangya Hospital, Central South UniversityClinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South UniversityAbstract Currently, evidence concerning the link between maximal aortic diameter and in-hospital mortality in cases of acute type B aortic dissection (ATBAD) is insufficient. Thus, this study aimed to explore the relationship between the maximal aortic diameter at the time of admission and the early prognosis of patients diagnosed with ATBAD. A total of 678 patients with ATBAD were included between January 2016 and December 2018, during which their clinical data was gathered. The independent variable analyzed was the maximal diameter of the aorta, while the dependent variable was mortality during hospitalization. Factors considered in this analysis included the patients’ age, gender, body mass index (BMI), medical history of hypertension, stroke, diabetes, atherosclerosis, smoking habits, chronic kidney insufficiency, time until presentation, systolic and diastolic blood pressures, ejection fraction, presence of aortic regurgitation, symptoms, involvement of abdominal vessels, laboratory findings, and treatment approaches. Of these patients collected, the mean age was 56.03 ± 12.22 years, and approximately 82.45% of them were male. After analysis, it was found that the maximal aortic diameter of patients with ATBAD was positively correlated with in-hospital mortality (OR = 1.06, 95% CI 1.03 to 1.10). Surprisingly, a J curve relationship was detected between maximal aortic diameter (point 31 mm) and in-hospital death for patients with ATBAD. The effect sizes and confidence intervals of the right (maximal aortic diameter > 31 mm) and left (maximal aortic diameter ≤ 31 mm) aspects of the inflection point were 1.06 (1.02–1.11) and 1.03 (0.83–1.28), respectively. In addition, the stratified analysis showed a stable relationship between maximal aortic diameter and in-hospital mortality, while there was no significant difference in the interaction between different subgroups. In patients with ATBAD, a J-curve relationship was identified between the maximal aortic diameter and in-hospital mortality. Specifically, when the maximal aortic diameter exceeds 31 mm, a positive correlation with in-hospital death was observed.https://doi.org/10.1038/s41598-024-77649-3Acute type B aortic dissectionMaximal aortic diameterIn-hospital mortality |
| spellingShingle | Xianming Tang Shuangfa Qiu Xin Sun Guifang Yang Lijuan Sheng The prognostic impact of maximal aortic diameter on acute type B aortic dissection progression in a Chinese population Scientific Reports Acute type B aortic dissection Maximal aortic diameter In-hospital mortality |
| title | The prognostic impact of maximal aortic diameter on acute type B aortic dissection progression in a Chinese population |
| title_full | The prognostic impact of maximal aortic diameter on acute type B aortic dissection progression in a Chinese population |
| title_fullStr | The prognostic impact of maximal aortic diameter on acute type B aortic dissection progression in a Chinese population |
| title_full_unstemmed | The prognostic impact of maximal aortic diameter on acute type B aortic dissection progression in a Chinese population |
| title_short | The prognostic impact of maximal aortic diameter on acute type B aortic dissection progression in a Chinese population |
| title_sort | prognostic impact of maximal aortic diameter on acute type b aortic dissection progression in a chinese population |
| topic | Acute type B aortic dissection Maximal aortic diameter In-hospital mortality |
| url | https://doi.org/10.1038/s41598-024-77649-3 |
| work_keys_str_mv | AT xianmingtang theprognosticimpactofmaximalaorticdiameteronacutetypebaorticdissectionprogressioninachinesepopulation AT shuangfaqiu theprognosticimpactofmaximalaorticdiameteronacutetypebaorticdissectionprogressioninachinesepopulation AT xinsun theprognosticimpactofmaximalaorticdiameteronacutetypebaorticdissectionprogressioninachinesepopulation AT guifangyang theprognosticimpactofmaximalaorticdiameteronacutetypebaorticdissectionprogressioninachinesepopulation AT lijuansheng theprognosticimpactofmaximalaorticdiameteronacutetypebaorticdissectionprogressioninachinesepopulation AT xianmingtang prognosticimpactofmaximalaorticdiameteronacutetypebaorticdissectionprogressioninachinesepopulation AT shuangfaqiu prognosticimpactofmaximalaorticdiameteronacutetypebaorticdissectionprogressioninachinesepopulation AT xinsun prognosticimpactofmaximalaorticdiameteronacutetypebaorticdissectionprogressioninachinesepopulation AT guifangyang prognosticimpactofmaximalaorticdiameteronacutetypebaorticdissectionprogressioninachinesepopulation AT lijuansheng prognosticimpactofmaximalaorticdiameteronacutetypebaorticdissectionprogressioninachinesepopulation |