Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus
Abstract It is unknown whether type 2 diabetes mellitus (T2DM) influences the vascular function response to aerobic exercise. We examined brachial artery flow-mediated dilation (FMD) and flow-mediated slowing (FMS) of pulse wave velocity (PWV), 10-and 60-min after a high-intensity interval exercise...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-10865-7 |
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| author | João Luís Marôco Inês Arrais Tiago Silvestre Marco Pinto Sérgio Laranjo João Magalhães Helena Santa-Clara Bo Fernhall Xavier Melo |
| author_facet | João Luís Marôco Inês Arrais Tiago Silvestre Marco Pinto Sérgio Laranjo João Magalhães Helena Santa-Clara Bo Fernhall Xavier Melo |
| author_sort | João Luís Marôco |
| collection | DOAJ |
| description | Abstract It is unknown whether type 2 diabetes mellitus (T2DM) influences the vascular function response to aerobic exercise. We examined brachial artery flow-mediated dilation (FMD) and flow-mediated slowing (FMS) of pulse wave velocity (PWV), 10-and 60-min after a high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) in adults with and without T2DM. Twelve older male adults with T2DM (57–84 years), and twenty-four healthy young and older adults (12 per group, aged 20–40 years and 57–76 years, respectively), completed an acute bout of HIIE, MICE, and a non-exercise condition. FMD was evaluated by the same researcher following standardized guidelines. FMS was calculated from the manufacturer’s PWV beta formulas. Central arterial stiffness was estimated via carotid-femoral PWV (cfPWV). %FMD was reduced (d= − 5.94%, 95% CI: − 10.50 to − 1.38%, p = 0.002), whereas %FMS increased (d = 4.55%, 95% CI: 0.62 to 8.48%, p = 0.01), 10-min after HIIE only in adults with T2DM, normalizing 60-min into recovery. Conversely, %FMD was increased (d = 5.33%, 95% CI: 0.76 to 9.89%, p = 0.009) 10-min after MICE only in adults with T2DM. cfPWV remained unchanged following HIIE and MICE in all groups. We report disease-associated vascular function responses to aerobic exercise suggesting both HIIE and MICE uncover transient vascular alterations in older adults with T2DM. |
| format | Article |
| id | doaj-art-6bc8ce9ffa5f4fc4b995a2fec6460c72 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-6bc8ce9ffa5f4fc4b995a2fec6460c722025-08-20T03:46:06ZengNature PortfolioScientific Reports2045-23222025-07-0115111610.1038/s41598-025-10865-7Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitusJoão Luís Marôco0Inês Arrais1Tiago Silvestre2Marco Pinto3Sérgio Laranjo4João Magalhães5Helena Santa-Clara6Bo Fernhall7Xavier Melo8Integrative Human Physiology Laboratory, Manning College of Nursing and Health Sciences, University of Massachusetts BostonGinásio Clube Português, Research and Development Department, GCP LabGinásio Clube Português, Research and Development Department, GCP LabGinásio Clube Português, Research and Development Department, GCP LabInstituto de Fisiologia, Faculdade de Medicina, Universidade de LisboaCentro Interdisciplinar de Estudo da Performance Humana, Faculdade de Motricidade Humana–Universidade de LisboaGinásio Clube Português, Research and Development Department, GCP LabIntegrative Human Physiology Laboratory, Manning College of Nursing and Health Sciences, University of Massachusetts BostonCentro Interdisciplinar de Estudo da Performance Humana, Faculdade de Motricidade Humana–Universidade de LisboaAbstract It is unknown whether type 2 diabetes mellitus (T2DM) influences the vascular function response to aerobic exercise. We examined brachial artery flow-mediated dilation (FMD) and flow-mediated slowing (FMS) of pulse wave velocity (PWV), 10-and 60-min after a high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) in adults with and without T2DM. Twelve older male adults with T2DM (57–84 years), and twenty-four healthy young and older adults (12 per group, aged 20–40 years and 57–76 years, respectively), completed an acute bout of HIIE, MICE, and a non-exercise condition. FMD was evaluated by the same researcher following standardized guidelines. FMS was calculated from the manufacturer’s PWV beta formulas. Central arterial stiffness was estimated via carotid-femoral PWV (cfPWV). %FMD was reduced (d= − 5.94%, 95% CI: − 10.50 to − 1.38%, p = 0.002), whereas %FMS increased (d = 4.55%, 95% CI: 0.62 to 8.48%, p = 0.01), 10-min after HIIE only in adults with T2DM, normalizing 60-min into recovery. Conversely, %FMD was increased (d = 5.33%, 95% CI: 0.76 to 9.89%, p = 0.009) 10-min after MICE only in adults with T2DM. cfPWV remained unchanged following HIIE and MICE in all groups. We report disease-associated vascular function responses to aerobic exercise suggesting both HIIE and MICE uncover transient vascular alterations in older adults with T2DM.https://doi.org/10.1038/s41598-025-10865-7 |
| spellingShingle | João Luís Marôco Inês Arrais Tiago Silvestre Marco Pinto Sérgio Laranjo João Magalhães Helena Santa-Clara Bo Fernhall Xavier Melo Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus Scientific Reports |
| title | Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus |
| title_full | Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus |
| title_fullStr | Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus |
| title_full_unstemmed | Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus |
| title_short | Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus |
| title_sort | vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus |
| url | https://doi.org/10.1038/s41598-025-10865-7 |
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