Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.

Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.

Prevention efforts for respiratory syncytial virus (RSV) have been advanced due to the recent isolation and characterization of antibodies that specifically recognize the prefusion conformation of the RSV fusion (F) glycoprotein. These potently neutralizing antibodies are in clinical development for...

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Main Authors: Morgan S A Gilman, Syed M Moin, Vicente Mas, Man Chen, Nita K Patel, Kari Kramer, Qing Zhu, Stephanie C Kabeche, Azad Kumar, Concepción Palomo, Tim Beaumont, Ulrich Baxa, Nancy D Ulbrandt, José A Melero, Barney S Graham, Jason S McLellan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005035
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