Neuropsychiatric comorbidities and associated factors in 182 Chinese children with tic disorders
Abstract Objective Tic disorders (TD) often present with associated neuropsychiatric comorbidities. This study aims to examine the clinical manifestations of TD in pediatric patients and explore the spectrum and features of neuropsychiatric comorbidities among Chinese children diagnosed with TD. Met...
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BMC
2024-12-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-024-05306-9 |
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| author | Huan Cheng Fang Ye Shu-Fang Liu Yuan-Mei Chen Jie Chen Xiao-Jing Xu |
| author_facet | Huan Cheng Fang Ye Shu-Fang Liu Yuan-Mei Chen Jie Chen Xiao-Jing Xu |
| author_sort | Huan Cheng |
| collection | DOAJ |
| description | Abstract Objective Tic disorders (TD) often present with associated neuropsychiatric comorbidities. This study aims to examine the clinical manifestations of TD in pediatric patients and explore the spectrum and features of neuropsychiatric comorbidities among Chinese children diagnosed with TD. Methods A retrospective analysis was conducted on pediatric TD cases newly diagnosed at our institution, using the Mini International Neuropsychiatric Interview for Children and Adolescents 5.0 to screen for comorbidities. Furthermore, a statistical analysis of clinical features was undertaken. Results The study enrolled 182 patients, comprising 140 males and 42 females. The diagnoses were distributed as follows: 65 cases of provisional TD, 29 cases of chronic TD, and 88 cases of Tourette syndrome. 94 (51.65%) patients presented with at least a single neuropsychiatric comorbid, while 40 (21.98%) patients exhibited two or more such comorbidities. TD is most frequently comorbid with attention-deficit hyperactivity disorder (33.52%, 61/182), oppositional defiant disorder (11.00%, 20/182) and current/previous manic/hypomanic episode (7.69%, 14/182). Children with comorbidities, compared to those without, experienced delayed diagnosis (P = 0.039), were more prone to developing vocal tics (simple vocal tics P = 0.030, complex vocal tics P < 0.001), lacked sibling companionship (P = 0.030), and exhibited more severe tics (P = 0.008). The prevalence of comorbidities was notably higher in children from single-parent households (93.3%) compared to those in two-parent families (P = 0.006). Individuals with multiple comorbidities had delayed diagnosis (P = 0.013), and notably experienced more triggering psychological factors such as pressure, anxiety, and anger. Sex, parents’ educational backgrounds and severity of tics significantly related to specific comorbidity occurrence. Conclusion We identified several factors associated with comorbidities in children with TD, which aiding doctors in recognizing the comorbidities that require attention. Simultaneously, these factors help guide family members in providing targeted education that supports the physical and mental development of affected children. |
| format | Article |
| id | doaj-art-6bbcbd5436fa4a63bf93d2b950761887 |
| institution | OA Journals |
| issn | 1471-2431 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj-art-6bbcbd5436fa4a63bf93d2b9507618872025-08-20T02:20:38ZengBMCBMC Pediatrics1471-24312024-12-012411910.1186/s12887-024-05306-9Neuropsychiatric comorbidities and associated factors in 182 Chinese children with tic disordersHuan Cheng0Fang Ye1Shu-Fang Liu2Yuan-Mei Chen3Jie Chen4Xiao-Jing Xu5Department of Pediatrics, China-Japan Friendship HospitalDepartment of Pediatrics, China-Japan Friendship HospitalDepartment of Pediatrics, China-Japan Friendship HospitalDepartment of Pediatrics, China-Japan Friendship HospitalDepartment of Pediatrics, China-Japan Friendship HospitalDepartment of Pediatrics, China-Japan Friendship HospitalAbstract Objective Tic disorders (TD) often present with associated neuropsychiatric comorbidities. This study aims to examine the clinical manifestations of TD in pediatric patients and explore the spectrum and features of neuropsychiatric comorbidities among Chinese children diagnosed with TD. Methods A retrospective analysis was conducted on pediatric TD cases newly diagnosed at our institution, using the Mini International Neuropsychiatric Interview for Children and Adolescents 5.0 to screen for comorbidities. Furthermore, a statistical analysis of clinical features was undertaken. Results The study enrolled 182 patients, comprising 140 males and 42 females. The diagnoses were distributed as follows: 65 cases of provisional TD, 29 cases of chronic TD, and 88 cases of Tourette syndrome. 94 (51.65%) patients presented with at least a single neuropsychiatric comorbid, while 40 (21.98%) patients exhibited two or more such comorbidities. TD is most frequently comorbid with attention-deficit hyperactivity disorder (33.52%, 61/182), oppositional defiant disorder (11.00%, 20/182) and current/previous manic/hypomanic episode (7.69%, 14/182). Children with comorbidities, compared to those without, experienced delayed diagnosis (P = 0.039), were more prone to developing vocal tics (simple vocal tics P = 0.030, complex vocal tics P < 0.001), lacked sibling companionship (P = 0.030), and exhibited more severe tics (P = 0.008). The prevalence of comorbidities was notably higher in children from single-parent households (93.3%) compared to those in two-parent families (P = 0.006). Individuals with multiple comorbidities had delayed diagnosis (P = 0.013), and notably experienced more triggering psychological factors such as pressure, anxiety, and anger. Sex, parents’ educational backgrounds and severity of tics significantly related to specific comorbidity occurrence. Conclusion We identified several factors associated with comorbidities in children with TD, which aiding doctors in recognizing the comorbidities that require attention. Simultaneously, these factors help guide family members in providing targeted education that supports the physical and mental development of affected children.https://doi.org/10.1186/s12887-024-05306-9Tic disordersTourette syndromeEvaluationNeuropsychiatric comorbiditiesAttention-deficit hyperactivity disorder |
| spellingShingle | Huan Cheng Fang Ye Shu-Fang Liu Yuan-Mei Chen Jie Chen Xiao-Jing Xu Neuropsychiatric comorbidities and associated factors in 182 Chinese children with tic disorders BMC Pediatrics Tic disorders Tourette syndrome Evaluation Neuropsychiatric comorbidities Attention-deficit hyperactivity disorder |
| title | Neuropsychiatric comorbidities and associated factors in 182 Chinese children with tic disorders |
| title_full | Neuropsychiatric comorbidities and associated factors in 182 Chinese children with tic disorders |
| title_fullStr | Neuropsychiatric comorbidities and associated factors in 182 Chinese children with tic disorders |
| title_full_unstemmed | Neuropsychiatric comorbidities and associated factors in 182 Chinese children with tic disorders |
| title_short | Neuropsychiatric comorbidities and associated factors in 182 Chinese children with tic disorders |
| title_sort | neuropsychiatric comorbidities and associated factors in 182 chinese children with tic disorders |
| topic | Tic disorders Tourette syndrome Evaluation Neuropsychiatric comorbidities Attention-deficit hyperactivity disorder |
| url | https://doi.org/10.1186/s12887-024-05306-9 |
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