Tractography of the corpus callosum in Huntington's disease.
White matter abnormalities have been shown in presymptomatic and symptomatic Huntington's disease (HD) subjects using Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) methods. The largest white matter tract, the corpus callosum (CC), has been shown to be particularly vulnerab...
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0073280&type=printable |
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| author | Owen Phillips Cristina Sanchez-Castaneda Francesca Elifani Vittorio Maglione Alba Di Pardo Carlo Caltagirone Ferdinando Squitieri Umberto Sabatini Margherita Di Paola |
| author_facet | Owen Phillips Cristina Sanchez-Castaneda Francesca Elifani Vittorio Maglione Alba Di Pardo Carlo Caltagirone Ferdinando Squitieri Umberto Sabatini Margherita Di Paola |
| author_sort | Owen Phillips |
| collection | DOAJ |
| description | White matter abnormalities have been shown in presymptomatic and symptomatic Huntington's disease (HD) subjects using Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) methods. The largest white matter tract, the corpus callosum (CC), has been shown to be particularly vulnerable; however, little work has been done to investigate the regional specificity of tract abnormalities in the CC. Thus, this study examined the major callosal tracts by applying DTI-based tractography. Using TrackVis, a previously defined region of interest tractography method parcellating CC into seven major tracts based on target region was applied to 30 direction DTI data collected from 100 subjects: presymptomatic HD (Pre-HD) subjects (n=25), HD patients (n=25) and healthy control subjects (n=50). Tractography results showed decreased fractional anisotropy (FA) and increased radial diffusivity (RD) across broad regions of the CC in Pre-HD subjects. Similar though more severe deficits were seen in HD patients. In Pre-HD and HD, callosal FA and RD were correlated with Disease Burden/CAG repeat length as well as motor (UHDRSI) and cognitive (URDRS2) assessments. These results add evidence that CC pathways are compromised prior to disease onset with possible demyelination occurring early in the disease and suggest that CAG repeat length is a contributing factor to connectivity deficits. Furthermore, disruption of these callosal pathways potentially contributes to the disturbances of motor and cognitive processing that characterize HD. |
| format | Article |
| id | doaj-art-6bb43314a849488b9ed021e7dd14873a |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-6bb43314a849488b9ed021e7dd14873a2025-08-20T03:46:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7328010.1371/journal.pone.0073280Tractography of the corpus callosum in Huntington's disease.Owen PhillipsCristina Sanchez-CastanedaFrancesca ElifaniVittorio MaglioneAlba Di PardoCarlo CaltagironeFerdinando SquitieriUmberto SabatiniMargherita Di PaolaWhite matter abnormalities have been shown in presymptomatic and symptomatic Huntington's disease (HD) subjects using Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) methods. The largest white matter tract, the corpus callosum (CC), has been shown to be particularly vulnerable; however, little work has been done to investigate the regional specificity of tract abnormalities in the CC. Thus, this study examined the major callosal tracts by applying DTI-based tractography. Using TrackVis, a previously defined region of interest tractography method parcellating CC into seven major tracts based on target region was applied to 30 direction DTI data collected from 100 subjects: presymptomatic HD (Pre-HD) subjects (n=25), HD patients (n=25) and healthy control subjects (n=50). Tractography results showed decreased fractional anisotropy (FA) and increased radial diffusivity (RD) across broad regions of the CC in Pre-HD subjects. Similar though more severe deficits were seen in HD patients. In Pre-HD and HD, callosal FA and RD were correlated with Disease Burden/CAG repeat length as well as motor (UHDRSI) and cognitive (URDRS2) assessments. These results add evidence that CC pathways are compromised prior to disease onset with possible demyelination occurring early in the disease and suggest that CAG repeat length is a contributing factor to connectivity deficits. Furthermore, disruption of these callosal pathways potentially contributes to the disturbances of motor and cognitive processing that characterize HD.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0073280&type=printable |
| spellingShingle | Owen Phillips Cristina Sanchez-Castaneda Francesca Elifani Vittorio Maglione Alba Di Pardo Carlo Caltagirone Ferdinando Squitieri Umberto Sabatini Margherita Di Paola Tractography of the corpus callosum in Huntington's disease. PLoS ONE |
| title | Tractography of the corpus callosum in Huntington's disease. |
| title_full | Tractography of the corpus callosum in Huntington's disease. |
| title_fullStr | Tractography of the corpus callosum in Huntington's disease. |
| title_full_unstemmed | Tractography of the corpus callosum in Huntington's disease. |
| title_short | Tractography of the corpus callosum in Huntington's disease. |
| title_sort | tractography of the corpus callosum in huntington s disease |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0073280&type=printable |
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