Treadmill training protects valproic acid-induced autistic features via cerebellar AMPK/PPAR-γ dependent pathway and improves mitochondrial activity in mice

Treadmill training protects valproic acid-induced autistic features via cerebellar AMPK/PPAR-γ dependent pathway and improves mitochondrial activity in mice

Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with impaired sociality and stereotypic behavior. Endurance training could modulate mitochondrial dysfunction sharing in the pathophysiology of ASD. We investigated the neuroprotective effects of training on VPA-indu...

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Bibliographic Details
Main Authors: Anwaar M. Shaban, Omnia Ameen, Marwa Omar, Sara A. El Derbaly, Hend R. Omara, Asmaa I. Bayomi, Asmaa A. Abdel Latif, Zainab Ibrahim Elakabawy, Suzan A. Khodir
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Autism
Training
AMPK
Irisin
PPAR-γ
Metrnl
Online Access:https://doi.org/10.1038/s41598-025-09089-6
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