Impact of helminth infections during pregnancy on maternal and newborn Vitamin D and on birth outcomes
Abstract Poor birth outcomes in low- and middle income countries are associated with maternal vitamin D deficiency and chronic helminth infections. Here, we investigated whether maternal Schistosoma haematobium affects maternal or cord vitamin D status as well as birth outcomes. In a prospective cro...
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Nature Portfolio
2024-06-01
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| Online Access: | https://doi.org/10.1038/s41598-024-65232-9 |
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| author | Sèyigbéna P. Déo-Gracias Berry Yabo Josiane Honkpèhedji Esther Ludwig Saïdou Mahmoudou Ulrich Fabien Prodjinotho Rafiou Adamou Odilon P. Nouatin Bayode R. Adégbitè Jean Claude Dejon-Agobe Romuald Beh Mba Moustapha Maloum Anne Marie Mouima Nkoma Jeannot Fréjus Zinsou Adrian J. F. Luty Meral Esen Ayôla Akim Adégnika Clarissa Prazeres da Costa |
| author_facet | Sèyigbéna P. Déo-Gracias Berry Yabo Josiane Honkpèhedji Esther Ludwig Saïdou Mahmoudou Ulrich Fabien Prodjinotho Rafiou Adamou Odilon P. Nouatin Bayode R. Adégbitè Jean Claude Dejon-Agobe Romuald Beh Mba Moustapha Maloum Anne Marie Mouima Nkoma Jeannot Fréjus Zinsou Adrian J. F. Luty Meral Esen Ayôla Akim Adégnika Clarissa Prazeres da Costa |
| author_sort | Sèyigbéna P. Déo-Gracias Berry |
| collection | DOAJ |
| description | Abstract Poor birth outcomes in low- and middle income countries are associated with maternal vitamin D deficiency and chronic helminth infections. Here, we investigated whether maternal Schistosoma haematobium affects maternal or cord vitamin D status as well as birth outcomes. In a prospective cross-sectional study of pregnant women conducted in Lambaréné, Gabon, we diagnosed maternal parasitic infections in blood, urine and stool. At delivery we measured vitamin D in maternal and cord blood. S. haematobium, soil-transmitted helminths, and microfilariae were found at prevalences of 30.2%, 13.0%, and 8.8%, respectively. Insufficient vitamin D and calcium levels were found in 28% and 15% of mothers, and in 11.5% and 1.5% of newborns. Mothers with adequate vitamin D had lower risk of low birthweight babies (aOR = 0.11, 95% CI 0.02–0.52, p = 0.01), whilst offspring of primipars had low cord vitamin D levels, and low vitamin D levels increased the risk of maternal inflammation. Maternal filariasis was associated with low calcium levels, but other helminth infections affected neither vitamin D nor calcium levels in either mothers or newborns. Healthy birth outcomes require maintenance of adequate vitamin D and calcium levels. Chronic maternal helminth infections do not disrupt those levels in a semi-rural setting in sub-Saharan Africa. |
| format | Article |
| id | doaj-art-6bb17c4933f04848a88f15e24b97cd8e |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-06-01 |
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| spelling | doaj-art-6bb17c4933f04848a88f15e24b97cd8e2025-08-20T02:22:33ZengNature PortfolioScientific Reports2045-23222024-06-0114111310.1038/s41598-024-65232-9Impact of helminth infections during pregnancy on maternal and newborn Vitamin D and on birth outcomesSèyigbéna P. Déo-Gracias Berry0Yabo Josiane Honkpèhedji1Esther Ludwig2Saïdou Mahmoudou3Ulrich Fabien Prodjinotho4Rafiou Adamou5Odilon P. Nouatin6Bayode R. Adégbitè7Jean Claude Dejon-Agobe8Romuald Beh Mba9Moustapha Maloum10Anne Marie Mouima Nkoma11Jeannot Fréjus Zinsou12Adrian J. F. Luty13Meral Esen14Ayôla Akim Adégnika15Clarissa Prazeres da Costa16Institute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich (TUM)Centre de Recherches Médicales de LambarénéInstitute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich (TUM)Centre de Recherches Médicales de LambarénéInstitute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich (TUM)Centre de Recherches Médicales de LambarénéInstitut de Recherche Clinique du Bénin (IRCB)Centre de Recherches Médicales de LambarénéCentre de Recherches Médicales de LambarénéCentre de Recherches Médicales de LambarénéCentre de Recherches Médicales de LambarénéCentre de Recherches Médicales de LambarénéCentre de Recherches Médicales de LambarénéMERIT, IRD, Université Paris CitéCentre de Recherches Médicales de LambarénéCentre de Recherches Médicales de LambarénéInstitute for Medical Microbiology, Immunology and Hygiene, TUM School of Medicine and Health, Technical University of Munich (TUM)Abstract Poor birth outcomes in low- and middle income countries are associated with maternal vitamin D deficiency and chronic helminth infections. Here, we investigated whether maternal Schistosoma haematobium affects maternal or cord vitamin D status as well as birth outcomes. In a prospective cross-sectional study of pregnant women conducted in Lambaréné, Gabon, we diagnosed maternal parasitic infections in blood, urine and stool. At delivery we measured vitamin D in maternal and cord blood. S. haematobium, soil-transmitted helminths, and microfilariae were found at prevalences of 30.2%, 13.0%, and 8.8%, respectively. Insufficient vitamin D and calcium levels were found in 28% and 15% of mothers, and in 11.5% and 1.5% of newborns. Mothers with adequate vitamin D had lower risk of low birthweight babies (aOR = 0.11, 95% CI 0.02–0.52, p = 0.01), whilst offspring of primipars had low cord vitamin D levels, and low vitamin D levels increased the risk of maternal inflammation. Maternal filariasis was associated with low calcium levels, but other helminth infections affected neither vitamin D nor calcium levels in either mothers or newborns. Healthy birth outcomes require maintenance of adequate vitamin D and calcium levels. Chronic maternal helminth infections do not disrupt those levels in a semi-rural setting in sub-Saharan Africa.https://doi.org/10.1038/s41598-024-65232-9Sub-Saharan AfricaHelminth infectionsMaternalNewborn vitamin DPregnancy outcomes |
| spellingShingle | Sèyigbéna P. Déo-Gracias Berry Yabo Josiane Honkpèhedji Esther Ludwig Saïdou Mahmoudou Ulrich Fabien Prodjinotho Rafiou Adamou Odilon P. Nouatin Bayode R. Adégbitè Jean Claude Dejon-Agobe Romuald Beh Mba Moustapha Maloum Anne Marie Mouima Nkoma Jeannot Fréjus Zinsou Adrian J. F. Luty Meral Esen Ayôla Akim Adégnika Clarissa Prazeres da Costa Impact of helminth infections during pregnancy on maternal and newborn Vitamin D and on birth outcomes Scientific Reports Sub-Saharan Africa Helminth infections Maternal Newborn vitamin D Pregnancy outcomes |
| title | Impact of helminth infections during pregnancy on maternal and newborn Vitamin D and on birth outcomes |
| title_full | Impact of helminth infections during pregnancy on maternal and newborn Vitamin D and on birth outcomes |
| title_fullStr | Impact of helminth infections during pregnancy on maternal and newborn Vitamin D and on birth outcomes |
| title_full_unstemmed | Impact of helminth infections during pregnancy on maternal and newborn Vitamin D and on birth outcomes |
| title_short | Impact of helminth infections during pregnancy on maternal and newborn Vitamin D and on birth outcomes |
| title_sort | impact of helminth infections during pregnancy on maternal and newborn vitamin d and on birth outcomes |
| topic | Sub-Saharan Africa Helminth infections Maternal Newborn vitamin D Pregnancy outcomes |
| url | https://doi.org/10.1038/s41598-024-65232-9 |
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